From osteoarthritis treatments to future regenerative therapies for cartilage

Clouet, Johann; Vinatier, Claire; Merceron, Christophe; Pot-Vaucel, Marianne; Maugars, Yves; Weiss, Pierre; Grimandi, G.; Guicheux, Jérôme

doi:10.1016/j.drudis.2009.07.012

Cited by 116 publications

(117 citation statements)

References 99 publications

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“…A prospective study on microfracture showed good to excellent in 67% of patients following a mean postoperative follow-up period of 3.6 years [14]. However, results of microfracture deteriorate over time due to the formation of fibrocartilage in the repair tissue [15,16].…”

Section: Introductionmentioning

confidence: 99%

Bioengineering of Articular Cartilage: Past, Present and Future

Felimban

Moulton

et al. 2013

Regen. Med.

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The treatment of cartilage defects poses a clinical challenge owing to the lack of intrinsic regenerative capacity of cartilage. The use of tissue engineering techniques to bioengineer articular cartilage is promising and may hold the key to the successful regeneration of cartilage tissue. Natural and synthetic biomaterials have been used to recreate the microarchitecture of articular cartilage through multilayered biomimetic scaffolds. Acellular scaffolds preserve the microarchitecture of articular cartilage through a process of decellularization of biological tissue. Although promising, this technique often results in poor biomechanical strength of the graft. However, biomechanical strength could be improved if biomaterials could be incorporated back into the decellularized tissue to overcome this limitation.

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Section: Introductionmentioning

confidence: 99%

Bioengineering of Articular Cartilage: Past, Present and Future

Felimban

Moulton

et al. 2013

Regen. Med.

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show abstract

“…Loss of proteoglycans and cleavage of collagen-2 occurs initially at the surface of articular cartilage, causing an increase in water content and reduced tensile strength of the matrix (Goldring & Goldring, 2007). Chondrocyte clustering is one of the typical features of OA cartilage (Clouet et al, 2009). Chondrocytes initially attempt to synthesize and replace degraded extracellular matrix (ECM) components such as collagen-2, -9, and -11, aggrecan, and pericellular collagen-4 (Buckwalter et al, 2007).…”

Section: Dysfunction Of Adult Articular Chondrocytes and Its Significmentioning

confidence: 99%

“…Due to the avascularity of articular cartilage, some nutrients are provided by diffusion of the synovial fluid. Articular chondrocytes have adapted to the very low oxygen tension (in the range of 1-7%) and low glucose levels with facilitated glucose transport via upregulation of hypoxia inducible factor-1 (HIF-1), expression of glucose transporter-1 and -3 (GLUT1 and GLUT3), and enhanced anaerobic glycolysis (Wilkins et al, 2000;Mobasheri et al, 2005;Clouet et al, 2009). Much like bone, the physiologic properties of articular cartilage are primarily related to the extracellular matrix, but homeostasis in adult articular cartilage relies on the function of articular chondrocytes.…”

Section: Dysfunction Of Adult Articular Chondrocytes and Its Significmentioning

confidence: 99%

Transcriptional Regulation of Articular Chondrocyte Function and Its Implication in Osteoarthritis

Wang¹,

Kramer²,

Schroeppel³

2012

Principles of Osteoarthritis- Its Definition, Character, Derivation and Modality-Related Recognition

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“…Intra-articular injections of corticosteroids (Habib et al, 2010) or hyaluronic acid (Liao et al, 2005) exert pain reducing effects that last for a couple of weeks but do not significantly improve the physical function of the joint. Nutritional supplements such as chondrotin sulphate and glucosamine are asymptomatic slow-acting safe drugs for the management of OA, but their efficacy in OA is questionable (Dougados, 2006) just like avocado, soybean, unsaponifiables and Vitamin E (Clouet et al, 2009). …”

Section: Non-pharmacological and Pharmacological Therapiesmentioning

confidence: 99%

“…Thus, the therapeutic efforts for OA specifically aim at the pain relief through the combination of non-pharmacological and pharmacological interventions. Non-pharmacological approaches include exercise therapy, weight loss, social support, self-management and awareness of patients to OA (Clouet et al, 2009). These approaches help partially prevent the disease, reduce pain and may delay the degenerative process in early-stage OA but do not offer a long-term remedy.…”

Section: Non-pharmacological and Pharmacological Therapiesmentioning

confidence: 99%