From Opportunity to Action

Likis, Frances E

doi:10.1111/jmwh.12471

Cited by 1 publication

(1 citation statement)

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“…Lack of folic acid in the body can lead to abnormal red blood cells and an increase in immature cells. [19] In vivo, folic acid acts as tetrahydrofolic acid, which is involved in synthesizing and converting purine nucleic acids, and pyrimidine nucleotides in vivo play a key role in DNA synthesis. [20] And folic acid plays an essential role in manufacturing nucleic acids (RNA, deoxyribonucleic acid).…”

Section: Discussionmentioning

confidence: 99%

Vitamin B12 as a novel risk biomarker of spinal fractures

Zheng

Xue

et al. 2022

Medicine

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Spinal fractures are common intra-articular fractures. Osteoporosis is a common and frequent disease among the elderly with a poor prognosis and a high risk of spinal fractures. However, the underlying factors for spinal fractures in patients with osteoporosis are unclear. A total of 105 patients with osteoporosis were recruited. Clinical and followed-up information was recorded. And vitamin B12, vitamin B2, vitamin A, and vitamin B9 in the blood were tested. Pearson's chi-squared and spearman tests were performed to analyze the correlation between spinal fractures and relative parameters. Univariate and multivariate logistic regression, univariate and multivariate Cox proportional hazards regression analysis. There exists strong relation between the expression level of vitamin B12 and spinal fractures. Pearson's chi-square and Spearman correlation test showed a strong association between vitamin B12 and vitamin B9 and a spinal fracture. Univariate logistic regression analysis showed that vitamin B12 and vitamin B9 were significantly associated with a spinal fracture. Multivariate logistic regression analysis showed that vitamin B12 was associated considerably with a spinal fracture. In addition, Cox regression analysis showed that vitamin B12 expression was significantly associated with maintenance time from recovery to recurrence (MTRR) of spinal fractures in patients with osteoporosis. Enhanced vitamin B12 is significantly correlated with the poor prognosis of patients with osteoporosis and the increasing incidence of a spinal fracture. The higher the vitamin B12, the higher the risk of spinal fracture and the shorter the time to spinal fracture recurrence.

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Section: Discussionmentioning

confidence: 99%