From neurotransmission to neuronal disorders

Abstract

In this issue on Neurochemistry in Japan, we provide an up-todate account of the current understanding of several aspects of neurochemistry. These include physiological processes such as neurotransmission with transcriptional and post-translational regulations, and memory formation together with pathological processes such as pain and neurodegenerative and psychiatric diseases such as Alzheimer's disease and depression. Also discussed are the pharmacological aspects, namely, how our current knowledge has translated into the future directions of clinical therapies. It consists of five authoritative state-of-the-art review articles and two original articles, one of which comes from our ally. tial treatment for patients with co-morbid depression and obesity.

Phosphatidylserine, inflammation, and central nervous system diseases

“…Neurotransmission is a biological process by which neurons transmit information and maintain normal functions of the brain. Structurally, the neurotransmitters which are packaged in synaptic vesicles are released by presynaptic membranes via calcium-dependent exocytosis and then bind to the receptor in the postsynaptic membrane and complete the signal transmission between neurons ( Kimura, 2021 ). PS is a component of the synaptic vesicle and involves several necessary neurotransmission steps.…”