From Neurons to Cognition: Technologies for Precise Recording of Neural Activity Underlying Behavior

Roth, Richard H.; Ding, Jun

doi:10.34133/2020/7190517

Cited by 12 publications

(8 citation statements)

References 221 publications

(280 reference statements)

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“…They conducted their research using a centrifugal particle receiver. According to their findings, increasing the cycle efficiency via the use of this arrangement would result in enhanced cycle efficiency, which was ascribed to an improvement in boiler efficiency owing to a reduction in stack losses [44][45] [46].…”

Section: Discussionmentioning

confidence: 99%

Solar Preheating in Power Plants: An Overview Of The Current State Of The Technology

Chen

zhuang

2021

ijasca

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Utilizing preheating units is one of the most critical ways to improve the performance of thermal power plants. Increasing the overall efficiency of Brayton or Rankine cycles by preheating the air or stream may result in considerable increases in output power and efficiency. When it comes to renewable energy, solar energy is an appealing alternative for use as a source of preheating since it is readily accessible. The current article discusses the use of solar energy for preheating air and steam in thermal power plants, as well as other uses. The performance of the systems is being improved, according to evaluations, as a result of a variety of elements, including the configuration of the reference system, the operating environment, the applied technology, and so on. Aside from improving the overall efficiency of the power plant, the incorporation of a solar preheating system may significantly decrease fuel usage and, as a result, carbon dioxide emissions. Furthermore, owing to the unavailability of solar energy during the night and overcast hours, thermal storage units may improve the system's dependability while also increasing the contribution of solar energy to the system's output.

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Section: Discussionmentioning

confidence: 99%

Solar Preheating in Power Plants: An Overview Of The Current State Of The Technology

Chen

zhuang

2021

ijasca

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“…FRET measurements are advantageous because the signal is independent of sensor expression level, and several improved FRET GECIs have been used in vivo (Horikawa et al, 2010; Mank et al, 2008; Shemetov et al, 2021; Thestrup et al, 2014). Nevertheless, to date, the most widely used GECIs are single fluorescent protein‐based GECIs, most notably the GCaMP family of sensors, for their generally larger response amplitudes (Akerboom et al, 2009; Lin & Schnitzer, 2016; Mank & Griesbeck, 2008; Nakai et al, 2001; Roth & Ding, 2020). Based on the prototype sensor camgaroo1, GCaMPs are constructed by flanking an environment‐sensitive cpGFP with calmodulin and another calmodulin‐binding peptide, RS20 (often mistaken for M13) from smooth muscle myosin light chain kinase (Baird et al, 1999; Nakai et al, 2001).…”

Section: Imaging Fast Transmission In Vivomentioning

confidence: 99%

Genetically encoded fluorescent sensors for imaging neuronal dynamics in vivo

Day-Cooney

Dalangin

Zhong

et al. 2022

Journal of Neurochemistry

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The brain relies on many forms of dynamic activities in individual neurons, from synaptic transmission to electrical activity and intracellular signaling events. Monitoring these neuronal activities with high spatiotemporal resolution in the context of animal behavior is a necessary step to achieve a mechanistic understanding of brain function. With the rapid development and dissemination of highly optimized genetically encoded fluorescent sensors, a growing number of brain activities can now be visualized in vivo. To date, cellular calcium imaging, which has been largely used as a proxy for electrical activity, has become a mainstay in systems neuroscience. While challenges remain, voltage imaging of neural populations is now possible. In addition, it is becoming increasingly practical to image over half a dozen neurotransmitters, as well as certain intracellular signaling and metabolic activities. These new capabilities enable neuroscientists to test previously unattainable hypotheses and questions. This review summarizes recent progress in the development and delivery of genetically encoded fluorescent sensors, and highlights example applications in the context of in vivo imaging.

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“…System-level mechanisms of cognition and action across networks of single neurons in awake, behaving mice remain largely elusive (Buzsaki, 2006;Aru, Suzuki and Larkum, 2020;Roth and Ding, 2020). The difficulty comes from recording neural activity over large spatial scales but with single neuron resolution during sensory and motor processes (Alivisatos et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Mesotrode: chronic simultaneous mesoscale cortical imaging and subcortical or peripheral nerve spiking activity recording in mice

Xiao

Yan

Murphy

2023

Preprint

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Brain function originates from hierarchical spatial-temporal neural dynamics distributed across cortical and subcortical networks. However, techniques available to assess large-scale brain network activity with single-neuron resolution in behaving animals remain limited. Here we present Mesotrode that integrates chronic wide-field mesoscale cortical imaging and compact multi-site cortical/subcortical cellular electrophysiology in head-fixed mice that undergo self-initiated running or orofacial movements. Specifically, we harnessed the flexibility of chronic multi-site tetrode recordings to monitor single-neuron activity in multiple subcortical structures while simultaneously imaging the mesoscale activity of the entire dorsal cortex. A mesoscale spike-triggered averaging procedure allowed the identification of cortical activity motifs preferentially associated with single-neuron spiking. Using this approach, we were able to characterize chronic single-neuron-related functional connectivity maps for up to 60 days post-implantation. Neurons recorded from distinct subcortical structures display diverse but segregated cortical maps, suggesting that neurons of different origins participate in distinct cortico-subcortical pathways. We extended the capability of Mesotrode by implanting the micro-electrode at the facial motor nerve and found that facial nerve spiking is functionally associated with the PTA, RSP, and M2 network, and optogenetic inhibition of the PTA area significantly reduced the facial movement of the mice. These findings demonstrate that Mesotrode can be used to sample different combinations of cortico-subcortical networks over prolonged periods, generating multimodal and multi-scale network activity from a single implant, offering new insights into the neural mechanisms underlying specific behaviors.

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From Neurons to Cognition: Technologies for Precise Recording of Neural Activity Underlying Behavior

Cited by 12 publications

References 221 publications

Solar Preheating in Power Plants: An Overview Of The Current State Of The Technology

Solar Preheating in Power Plants: An Overview Of The Current State Of The Technology

Genetically encoded fluorescent sensors for imaging neuronal dynamics in vivo

Mesotrode: chronic simultaneous mesoscale cortical imaging and subcortical or peripheral nerve spiking activity recording in mice

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