From multi-residue screening to target analysis of pharmaceuticals in water: Development of a new approach based on magnetic sector mass spectrometry and application in the Nairobi River basin, Kenya

K'Oreje, Kenneth; Demeestere, Kristof; Wispelaere, Patrick De; Vergeynst, Leendert; Dewulf, Jo; Langenhove, Herman Van

doi:10.1016/j.scitotenv.2012.07.052

Cited by 139 publications

(37 citation statements)

References 51 publications

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“…This result was quite different from previous reports for wastewater in Japan and Europe in which oseltamivir and oseltamivir acid were frequently detected (Fick et al, 2007;Ghosh et al, 2009Ghosh et al, , 2010aPrasse et al, 2010;Soderstrom et al, 2009;Singer et al, 2008;Slater et al, 2011). In addition, abacavir, lamivudine, nevirapine, penciclovir, stavudine, and zidovudine were detected at several to hundreds of ng L −1 in the wastewater of Germany (Prasse et al, 2010) whereas the concentrations of lamivudine and nevirapine were approximately 1 μg L −1 in treated wastewater in Kenya (Koreje et al, 2012). This may reflect difference in consumption of antiviral drugs in different countries.…”

Section: Distribution and Behavior Of The Antiviral Drugs In The Wastcontrasting

confidence: 94%

“…For instance, zidovudine, oseltamivir, and oseltamivir acid were detected in German rivers with maximum concentrations of 170, 15, 24 ng L −1 , respectively (Prasse et al, 2010). Oseltamivir and oseltamivir acid were up to 288 ng L −1 in river waters of Japan during influenza outbreak seasons (Azuma et al, 2012), and the highest concentration measured for zidovudine was up to 9 μg L −1 in Nairobi river water, Kenya, which was ascribed to high HIV/AIDS prevalence in that region (Koreje et al, 2012). In contrast, acyclovir that was widely detected in the Pearl River catchment in this work was not detected in Nairobi river basin.…”

Section: Antiviral Drugs In the River Watermentioning

confidence: 91%

“…Prasse et al (2010Prasse et al ( , 2011 have also reported the presence of other antivirals, including acyclovir and its metabolite carboxy-acyclovir, zidovudine, lamivudine, abacavir, and penciclovir in wastewater, river water, and even groundwater in Germany. Zidovudine, lamivudine, and nevirapine were detected in rivers in Kenya at μg L −1 level (Koreje et al, 2012). Biodegradation, photodegradation, and ozonation of oseltamivir and its carboxylates have been studied via bench-scale experiments as well as investigations in sewage treatment plants (Accinelli et al, 2007(Accinelli et al, , 2010aBartels and von Tumpling, 2008;Ghosh et al, 2010a,b;Goncalves et al, 2011;Mestankova et al, 2012;Sacca et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Profile and behavior of antiviral drugs in aquatic environments of the Pearl River Delta, China

Peng

Wang

Zhang

et al. 2014

Science of The Total Environment

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Section: Distribution and Behavior Of The Antiviral Drugs In The Wastcontrasting

confidence: 94%

Section: Antiviral Drugs In the River Watermentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Profile and behavior of antiviral drugs in aquatic environments of the Pearl River Delta, China

Peng

Wang

Zhang

et al. 2014

Science of The Total Environment

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“…Because of their chemical composition (the combination of lipophilic divinylbenzene and hydrophilic N-vinylpyrrolidone polymers), they are capable of extracting acidic, neutral and basic compounds at a wide range of pH values including neutral pH. 8,[21][22][23][24][25][26] EDTA was used as a chelating agent, it is recommended in the analysis of antibiotic residues in environmental samples. A chelating agent was added to water samples, prior to extraction, in order to chelate metals that are found in water, making possible to achieve good extraction efficiencies.…”

Section: Spe Proceduresmentioning

confidence: 99%

Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry Methods for Determination of Beta-Lactams, Macrolides, Fluoroquinolones, Sulfonamides and Tetracyclines in Surface and Drinking Water from Rio de Janeiro, Brazil

Monteiro¹,

Spisso²,

Ferreira³

et al. 2017

J. Braz. Chem. Soc.

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Two analytical methods for determination of five antibiotics classes in surface water and drinking water samples were developed and validated based on solid phase extraction followed by high-performance liquid chromatography coupled to tandem mass spectrometry. Two distinct chromatographic gradients were used according to the polarity of the different pharmaceuticals. The methods were applied for the quantification of 46 analytes belonging to beta-lactams, macrolides, fluoroquinolones, sulfonamides and tetracyclines classes. Validation results showed recoveries above 75% for the studied analytes in water samples. The method limits of detection calculated for the surface water and drinking water samples were, respectively, from 1 to 12 ng L -1 and from 0.15 to 20 ng L -1 . The method limit of quantification ranged from approximately 3 to 38 ng L -1 for surface water samples and from 0.5 to 64 ng L -1 for drinking water samples. The methods showed to be linear over the range of 25 to 1000 ng L -1 with coefficients of determination greater than 0.94. Amoxicillin, cephalexin and sulfamethoxazole as high as 105 ng L -1 were found in surface water and erythromycin, azithromycin and clarithromycin up to 35 ng L -1 could also be found in surface water. Clarithromycin, cefaclor, oxacillin, sulfamethoxazole and troleandomycin were detected in the lower range up to 10 ng L -1 in drinking water.

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“…In China, in surface water samples, oxytetracycline was detected at a level of 2.2 ng•L −1 [36]. Tetracyclines were detected in river waters around the world in a much lesser extent than sulfonamides.…”

Section: River Water Analysismentioning

confidence: 99%

Occurrence of Antimicrobials in River Water Samples from Rural Region of the State of Rio de Janeiro, Brazil

Monteiro¹,

Spisso²,

Santos³

et al. 2016

JEP

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The occurrence of antimicrobials in the aquatic environment and drinking water has raised the question of their impact on the environment and public health. Animal production is one of the most expressive activities of Brazilian agribusiness. In order to ensure the productivity and competitiveness of the sector, the use of drugs for therapeutic and prophylactic purposes is a common practice. Due to the continuous release of antimicrobials into the environment, the aim of this study was to compare the frequency of detection of tetracyclines and sulfonamides in surface water collected from rural areas in Lidice District of Rio Claro, in the State of Rio de Janeiro, Brazil. An investigative study was conducted with 24 river water samples analyzed by high-performance liquid chromatography coupled to tandem mass spectrometry and the aim of this study was to determine residues of sulfonamides and tetracyclines based on the USEPA me- M. A. Monteiro et al.231

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From multi-residue screening to target analysis of pharmaceuticals in water: Development of a new approach based on magnetic sector mass spectrometry and application in the Nairobi River basin, Kenya

Cited by 139 publications

References 51 publications

Profile and behavior of antiviral drugs in aquatic environments of the Pearl River Delta, China

Profile and behavior of antiviral drugs in aquatic environments of the Pearl River Delta, China

Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry Methods for Determination of Beta-Lactams, Macrolides, Fluoroquinolones, Sulfonamides and Tetracyclines in Surface and Drinking Water from Rio de Janeiro, Brazil

Occurrence of Antimicrobials in River Water Samples from Rural Region of the State of Rio de Janeiro, Brazil

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