From Mud and Stick-walled Houses to Corrugated Iron sheet Houses: A New Strategy for Preventing Human-Vector Contact in Marigat Sub-county a Leishmaniasis-endemic Area in Kenya

KiarieMakara, Martha; Nzau, Anna; Ngumbi, Philip M.; Waithima, Abraham; Bowen, M.R.; Ngure, Peter

doi:10.5455/ijtmph/246950

Cited by 1 publication

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References 18 publications

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“…As of 2019, 75% of the 153,000 population had never been to school [36]. Individuals predominately live in handmade huts with mud walls and grass roofs dispersed throughout the region and grow crops or care for livestock [36][37][38]. Many patients travel long distances to reach CSCH.…”

Section: Study Design Area and Populationmentioning

confidence: 99%

Visceral leishmaniasis follow-up and treatment outcomes in Tiaty East and West sub-counties, Kenya: Cure, relapse, and Post Kala-azar Dermal Leishmaniasis

Kennedy,

O’Brien,

Nyakundi

et al. 2024

PLoS ONE

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Background Visceral Leishmaniasis (VL) is a neglected tropical disease (NTD) with the highest regional burden in East Africa. Relapse and Post Kala-azar Dermal Leishmaniasis (PKDL) contribute to the spread of VL in endemic areas, making their surveillance imperative for control and elimination. Little is known about long-term patient outcomes in Kenya through follow-up after VL treatment, despite its requirement for control and elimination by the World Health Organization (WHO) and the Kenya Ministry of Health (KMOH). Methodology/Principal findings 36 follow-up patients in Tiaty East and West, sub-counties, Kenya, and records from 248 patients at the regional Chemolingot Sub-county Hospital (CSCH) were analyzed separately using Fisher’s Exact Tests, two-sample t-tests, and Welch’s t-tests in R (Version 4.3.0). The study found a prevalence rate of 88.89% (n = 32) final cure, 5.56% (n = 2) relapse, and 5.56% (n = 2) PKDL in follow-up patients and 92.74% (n = 230) initial cure, 6.86% (n = 17) relapse, and 0.80% (n = 2) PKDL in overall CSCH patients. The mean lengths of time at which follow-up patients relapsed and developed PKDL were 4.5 and 17 months, respectively. Young age (p = 0.04, 95% CI 0.63–24.31), shorter length of time from initial treatment to follow-up (p = 0.002, 95% CI 1.03-∞), lower Hb level at primary treatment (p = 0.0002, 95% CI 1.23–3.24), and living in Tiaty East sub-county (p = 0.04, 95% CI 0.00–1.43) were significantly associated (p<0.05) with VL relapse in follow-up study patients. Female sex (p = 0.04, 95% CI 0.84-∞) and living in Tiaty East sub-county (p = 0.03, 95% CI 0.00–1.43) were significantly associated with PKDL in follow-up study patients. Conclusions/Significance More research should be done on PKDL in Kenya with active follow-up to understand its true burden. These results on prevalence and risk factors for PKDL and relapse in Kenya should inform knowledge of patient outcomes and interventions in the region.

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Section: Study Design Area and Populationmentioning

confidence: 99%

Visceral leishmaniasis follow-up and treatment outcomes in Tiaty East and West sub-counties, Kenya: Cure, relapse, and Post Kala-azar Dermal Leishmaniasis

Kennedy,

O’Brien,

Nyakundi

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

From Mud and Stick-walled Houses to Corrugated Iron sheet Houses: A New Strategy for Preventing Human-Vector Contact in Marigat Sub-county a Leishmaniasis-endemic Area in Kenya

Abstract: Some of the authors of this publication are also working on these related projects: Effects of glucocorticoids in leishmania View project A three-pronged approach to the control of leishmaniasis in Marigat District, Baringo County, Kenya". View project

Cited by 1 publication

References 18 publications

Visceral leishmaniasis follow-up and treatment outcomes in Tiaty East and West sub-counties, Kenya: Cure, relapse, and Post Kala-azar Dermal Leishmaniasis

Visceral leishmaniasis follow-up and treatment outcomes in Tiaty East and West sub-counties, Kenya: Cure, relapse, and Post Kala-azar Dermal Leishmaniasis

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