From macro- to microscale poroelastic characterization of polymeric hydrogels via indentation

Kalcioglu, Z. Ilke; Mahmoodian, Roza; Hu, Yuhang; Suo, Zhigang; Vliet, Krystyn J. Van

doi:10.1039/c2sm06825g

Cited by 154 publications

(136 citation statements)

References 24 publications

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“…The stress-stretch curve of a hydrogel or an elastomer often depends on loading history due to various inelastic processes such as the Mullins effect [37,38], viscoelasticity [39][40][41][42][43], poroelasticity [42][43][44][45][46] and viscoplasticity [47]. In particular, the Mullins effect has been considered as the major factor to explain the softening of double network hydrogels over consecutive loading cycles [48][49][50][51][52][53][54], and has been attributed to progressive damage of the polymer networks [50,55].…”

Section: Shakedown After Prolonged Cyclingmentioning

confidence: 99%

Fatigue fracture of tough hydrogels

Bai

Yang

Tang

et al. 2017

Extreme Mechanics Letters

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233

186

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Abstract:Tough hydrogels of many chemical compositions have been developed in recent years, but their fatigue fracture has not been studied. The lack of study hinders further development of hydrogels for applications that require long lifetimes under cyclic loads. Examples include tissue engineering, soft robots, and stretchable electronics. Here we study the fatigue fracture of a polyacrylamide-alginate tough hydrogel. We find that the stress-stretch curve changes cycle by cycle, and reaches a steady state after thousands of cycles. The threshold for fatigue fracture is about 53 J/m 2 , much below the fracture energy (~10,000 J/m 2 ) measured under monotonic load. Nonetheless, the extension of crack per cycle in the polyacrylamide-alginate tough hydrogel is much smaller than that in a single-network polyacrylamide hydrogel.

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Section: Shakedown After Prolonged Cyclingmentioning

confidence: 99%

Fatigue fracture of tough hydrogels

Bai

Yang

Tang

et al. 2017

Extreme Mechanics Letters

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233

186

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“…27, 2018; instantaneous compression, and held for a test time of 5 seconds. This process has been described elsewhere, but in brief, the instantaneous force was normalized to the far-field force and fitted to a finite element analysis formula by modulating the characteristic time and material properties (shear modulus, diffusion) [50][51][52][53].…”

Section: Determination Of Poroelastic Propertiesmentioning

confidence: 99%

Mesenchymal stromal cell remodeling of a gelatin hydrogel microenvironment defines an artificial hematopoietic stem cell niche

Gilchrist

Lee

et al. 2018

Preprint

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We identify a combination of an initially low-diffusivity (autocrine dominated) hydrogel and a 1:1 HSCP:MSC seeding ratio as conducive to enhanced HSC population maintenance. Further, gene expression and serial mechanical testing data suggests that MSC-mediated matrix remodeling is significant for the long-term HSC culture, reducing HSC autocrine feedback and potentially enhancing MSC-mediated paracrine signaling over 7-day culture in vitro. This work demonstrates the design of an HSC culture system that couples initial hydrogel properties, MSC co-culture, and concepts of dynamic reciprocity mediated by MSC remodeling to achieve enhanced HSC maintenance.

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“…Indentation has frequently been used as an experimental method for measuring the elastic and kinetic properties of gels (Cai et al 2010;Hu et al 2010;Kalcioglu et al 2012). Following Hu et al (2010), we consider a two-dimensional planestrain problem, in which a gel is indented by a cylindrical indenter, as shown in figure 5.…”

Section: (B) Indenting a Visco-poroelastic Gelmentioning

confidence: 99%

“…There are possible scenarios in which such a simplification is not applicable. The first is the characterization of a local mechanical property of a gel or that of a micro-gel particle, at length scale below micrometres, such as nano-indentation (Kalcioglu et al 2012) and micro-rheology (Dutta & Belfort 2007;Chen et al 2010;Patre & Toomey 2010). In this case, the short length for solvent migration reduces the swelling time to a value comparable to the characteristic time of viscoelasticity, and the deformation appears to be dominantly viscoelastic (Chen et al 2010).…”

Section: Introductionmentioning

confidence: 99%

“…In §4, we give numerical examples of our model, including the behaviour of a gel in confined and unconfined uniaxial deformation and compression by a cylindrical indenter. Specifically, we seek to elucidate the separation of viscoelastic and poroelastic processes through changes in length scales (Kalcioglu et al 2012;Mohan et al submitted).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A visco-poroelastic theory for polymeric gels

Wang

Hong

2012

Proc. R. Soc. A.

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A polymeric gel can imbibe solvent and swell. Besides the dilatational mode of deformation, which involves long-range solvent migration, a gel may also undergo volume-conserved deformation. For a macroscopic gel with covalent cross-links, the volume-conserved deformation is usually much faster. However, these two modes are coupled for deformation at the microscopic level and for gels containing physical cross-links or large solvent molecules. In this paper, we seek to formulate a unified theoretical framework for the transient behaviour of polymeric gels to account for both solvent migration and viscoelastic deformation. Under this framework, we further develop a simple material model, and implement it into a finite-element code for numerical calculations. By simultaneously tracking the solvent migration and motion of polymer network, we evolve the inhomogeneous fields of stress and chemical potential. Several initial-boundary-value problems are solved as illustrative examples. For macroscopic gels with low viscosity, the time scales for viscoelasticity and poroelasticity are separated, and the long-term behaviour is just as that predicted by a poroelastic model. For structures or processes involving sizes comparable to the intrinsic length of a material, the viscoelasticity and poroelasticity must be considered simultaneously, especially when studying impact responses.

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From macro- to microscale poroelastic characterization of polymeric hydrogels via indentation

Cited by 154 publications

References 24 publications

Fatigue fracture of tough hydrogels

Fatigue fracture of tough hydrogels

Mesenchymal stromal cell remodeling of a gelatin hydrogel microenvironment defines an artificial hematopoietic stem cell niche

A visco-poroelastic theory for polymeric gels

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