From leptin to other adipokines in health and disease: Facts and expectations at the beginning of the 21st century

Blüher, Matthias; Mantzoros, Christos S.

doi:10.1016/j.metabol.2014.10.016

Cited by 351 publications

(296 citation statements)

References 201 publications

(254 reference statements)

Supporting

Mentioning

259

Contrasting

Unclassified

Order By: Relevance

“…Adiponectin is highly abundant in plasma and is a key cytokine in energy homeostasis, www.chinaphar.com Yuan YM et al Acta Pharmacologica Sinica npg regulating both glucose and lipid metabolism. In humans, down regulation of adiponectin and its receptors is associated with systemic inflammation and extrapulmonary effects, such as weight loss, osteoporosis, adipose atrophy, and skeletal muscle atrophy associated with age [6] . Recent human studies have demonstrated a significant increase in serum adiponectin levels in COPD and a direct correlation of these levels to the severity of the disease [7,8] .…”

Section: Introductionmentioning

confidence: 99%

Genetic variants of CDH13 determine the susceptibility to chronic obstructive pulmonary disease in a Chinese population

Yuan

Zhang

et al. 2016

Acta Pharmacol Sin

View full text Add to dashboard Cite

Aim: Adiponectin has been implicated in the development of chronic obstructive pulmonary disease (COPD). The CDH13 gene encodes T-cadherin that is an adiponectin receptor, and genetic variants of CDH13 determine blood adiponectin levels. The aim of this study was to investigate the effects of CDH13 variants on COPD susceptibility in a Chinese population. Methods: Ten single-nucleotide polymorphisms (SNP) in CDH13 were screened using the SNaPshot method in 279 COPD patients and 367 control subjects. Association of genotypes or haplotypes constructed from these loci with COPD was analyzed in different genetic models. Results: Among the 10 SNPs tested, rs4783244 and rs12922394 exhibited significant differences in allele or genotype frequencies between COPD patients and control subjects, whereas 8 other SNPs did not. The minor allele T was associated with decreased risk of COPD in the recessive model at rs4783244 (OR=0.42, P=0.023) and in the dominant model at rs12922394 (OR=0.70, P=0.022). The genotype TT at either rs4783244 or rs12922394 was associated with a significantly low level of plasma adiponectin when compared to genotypes GG and CC (P<0.05). Haplotypes GC in block 1 (rs4783244-rs12922394) as well as GTAC and ATGT in block 3 (rs4783266-rs11640522-rs11646849-rs11860282) significantly increased the risk of COPD, whereas haplotypes TT in block 1, TG in block 2 (rs11646011-rs11640875) and ATGC in block 3 were protective against COPD. Conclusion: CDH13 genetic variants determine Chinese individuals' susceptibility to COPD and thus are efficient genetic biomarkers for early detection of COPD.

show abstract

Section: Introductionmentioning

confidence: 99%

Genetic variants of CDH13 determine the susceptibility to chronic obstructive pulmonary disease in a Chinese population

Yuan

Zhang

et al. 2016

Acta Pharmacol Sin

View full text Add to dashboard Cite

show abstract

“…Another distinct feature is that adiponectin has been found to be inversely related to anthropometric measures, such as BMI and waist circumference [5,9,10], and to other metabolic factors found to be associated with higher risk of type 2 diabetes, CHD and hypertension, for example circulating insulin, glucose and triglyceride concentrations [4][5][6]9,10]. Furthermore, numerous animal studies have reported that adiponectin exerts direct anti-inflammatory, anti-atherogenic, antihypertensive (vasodilatory) and antidiabetic (insulinsensitizing) properties [11][12][13][14]. Nevertheless, even though adiponectin has been associated with well-known cardiovascular risk factors [4][5][6][8][9][10], a number of studies have failed to show any association between hypoadiponectinaemia and cardiovascular events in human beings, as summarized in three recent systematic reviews and meta-analyses [15][16][17].…”

mentioning

confidence: 99%

Similar Adiponectin Levels in Obese Normotensive and Obese Hypertensive Men and No Vasorelaxant Effect of Adiponectin on Human Arteries

Dreier

Asferg

Berg

et al. 2015

Basic Clin Pharma Tox

View full text Add to dashboard Cite

Obesity is a strong risk factor for hypertension, but the mechanism linking obesity to hypertension is not fully elucidated. In obesity, circulating concentrations of adiponectin are decreased and hypoadiponectinaemia has in some but not all studies been associated with increased risk of hypertension. Due to this inconsistency, we decided to study adiponectin from two aspects in a cross-sectional in vivo study and in an experimental in vitro study. In the cross-sectional study, 103 men with body mass index (BMI) ≥ 30.0 kg/m 2 were studied; 63 had 24-hr ambulatory blood pressure (ABP) ≥ 130/80 mmHg (ObeseHT) and 40 had 24-hr ABP < 130/80 mmHg (ObeseNT). As controls, we studied 27 men with BMI between 20.0 and 24.9 kg/m 2 and 24-hr ABP < 130/80 mmHg (LeanNT). Serum concentrations of adiponectin and body composition using dual-energy X-ray absorptiometry scanning were determined. In vitro, the direct vasomotor response of adiponectin was tested on subcutaneous resistance arteries from human abdominal adipose tissue. The two obese groups had lower adiponectin concentrations compared with LeanNT (p < 0.01) [median (interquartile range)]: ObeseHT 6.5 (5.1-8.3) mg/L; ObeseNT 6.6 (5.2-7.8) mg/L; and LeanNT 9.4 (6.7-12.4) mg/L, with no significant difference in adiponectin concentrations (or body composition) between ObeseHT and ObeseNT (p = 0.67). In vitro, adiponectin did not have any direct vasodilatory effect and adiponectin did not affect angiotensin II-stimulated vasoconstriction. In conclusion, obese hypertensive men have similar serum concentrations of adiponectin as obese normotensive men. In combination with the in vitro data, these findings question a pathogenic role of adiponectin in human hypertension.High body mass index (BMI) caused by excessive growth of adipose tissue is a major risk factor for hypertension [1], but the mechanisms by which excess adipose tissue leads to hypertension are still not fully elucidated [2,3].Over the past decades, it has become increasingly apparent that adipose tissue is not only a passive energy store, but also an active endocrine and paracrine organ that secretes various proinflammatory, vasoactive and metabolic active substances, collectively called adipocytokines or just adipokines [4][5][6][7][8]. Based on both animal and human studies, it has been suggested that these active adipose tissue-derived substances could play a role in overweight-related diseases, such as type 2 diabetes, coronary heart disease (CHD) and hypertension [4][5][6][7][8].Adiponectin, a 244 amino acid protein, which is secreted from adipose tissue, is one of these adipocytokines [4][5][6][8][9][10]. Compared with other adipocytokines, adiponectin is distinct in the sense that lower (hypoadiponectinaemia) rather than higher (hyperadiponectinaemia) circulating concentrations of adiponectin have been associated with increased risk of overweight-related diseases [4][5][6][8][9][10]. Another distinct feature is that adiponectin has been found to be inversely related to anthropometric measures, ...

show abstract

“…

…”

unclassified

“…Це знайшло своє вiдображення у формуваннi концепцiї щодо ендокринної функцiї жирової тканини, яка секретує безлiчь бiологiчно активних мо-лекул включно з гормонами, що отримали назву адипокiни. Завдяки адипокiнам жи-рова тканина впливає на регуляцiю цiлого ряду важливих фiзiологiчних функцiй орга-нiзму, таких як апетит, ситiсть, витрачання енергiї, чутливiсть до iнсулiну та його се-крецiя, вуглеводний та лiпдний метаболiзм, розподiл жиру, ендотелiальна функцiя, ге-мостаз, кров'яний тиск, нейроендокринная регуляцiя та функцiя iмунної системи [1]. У зв'язку з вищенаведеним адипокiни ма-ють великий потенцiал для клiнiчного ви-користання в якостi можливих терапевти-чних засобiв у лiкуваннi ожирiння й асо-цiйованих метаболiчних, кардiоваскулярних * Роботу виконано в рамках укладеного договору про сумiсну наукову дiяльнiсть без взаємних фiнансових зобов'язань мiж Харкiвською академiєю пiслядипломної освiти, ДУ Iнститут проблем ендокринної патологiї iм.…”

unclassified

“…Оментин-1 експресується у значнiй кiлькостi вiсцеральною жировою тканиною, та значно менше пiдшкiрним жиром. Вiн присутнiй у стромальних клiти-нах судин жирової тканини сальника, але не в зрiлих жирових клiтинах [1,6]. Оментин-1 людини це бiлок, який складається з 313 амiнокислот та мiстить секреторну сигналь-ну послiдовнiсть i домен, родинний фiбри-ногену [5,7].…”

unclassified

See 1 more Smart Citation

Оментин-1 У Хворих На Цукровий Дiабет 2 Типу: Зв'язок З Атерогенезом

Gorshunska¹

2015

PEP

View full text Add to dashboard Cite

У цьому роцi виповнюється 20 рокiв з моменту вiдкриття лептину, яке призве-ло до величезного сплеску iнтенсивностi до-слiджень бiохiмiї ожирiння [1]. Це знайшло своє вiдображення у формуваннi концепцiї щодо ендокринної функцiї жирової тканини, яка секретує безлiчь бiологiчно активних мо-лекул включно з гормонами, що отримали назву адипокiни. Завдяки адипокiнам жи-рова тканина впливає на регуляцiю цiлого ряду важливих фiзiологiчних функцiй орга-нiзму, таких як апетит, ситiсть, витрачання енергiї, чутливiсть до iнсулiну та його се-крецiя, вуглеводний та лiпдний метаболiзм, розподiл жиру, ендотелiальна функцiя, ге-мостаз, кров'яний тиск, нейроендокринная регуляцiя та функцiя iмунної системи [1]. У зв'язку з вищенаведеним адипокiни ма-ють великий потенцiал для клiнiчного ви-користання в якостi можливих терапевти-чних засобiв у лiкуваннi ожирiння й асо-цiйованих метаболiчних, кардiоваскулярних * Роботу виконано в рамках укладеного договору про сумiсну наукову дiяльнiсть без взаємних фiнансових зобов'язань мiж Харкiвською академiєю пiслядипломної освiти, ДУ Iнститут проблем ендокринної патологiї iм. В. Я. Данилевського НАМН України та Нацiональним iнститутом охорони громадського здоров'я та екологiї, м. Бiлтховен, Нiдерланди (узгодження б/н RIVM вiд 18.10.2008 р.) Адипоцитокiни та патерн чутливостi до iнсулiну у хворих на цукровий дiабет 2 типу, що лiкувалися n-3 полiненасиченими жирними кислотами .Автор гарантує вiдповiдальнiсть за все, що опублiковано в статтi. Автор гарантує вiдсутнiсть конфлiкту iнтересiв та власної фiнансової зацiкавленостi при виконаннi роботи та написаннi статтi.. Рукопис надiйшов до редакцiї 13.02.2015.Проблеми ендокринної патологiї № 2, 2015 15http://dx

show abstract

From leptin to other adipokines in health and disease: Facts and expectations at the beginning of the 21st century

Cited by 351 publications

References 201 publications

Genetic variants of CDH13 determine the susceptibility to chronic obstructive pulmonary disease in a Chinese population

Genetic variants of CDH13 determine the susceptibility to chronic obstructive pulmonary disease in a Chinese population

Similar Adiponectin Levels in Obese Normotensive and Obese Hypertensive Men and No Vasorelaxant Effect of Adiponectin on Human Arteries

Оментин-1 У Хворих На Цукровий Дiабет 2 Типу: Зв'язок З Атерогенезом

Contact Info

Product

Resources

About