From laboratory to environmental conditions: a new approach for chemical’s biodegradability assessment

Brillet, F.; Armand, Michel; Durand, M.; Thouand, Gérald

doi:10.1007/s11356-016-7062-x

Cited by 20 publications

(16 citation statements)

References 32 publications

(26 reference statements)

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“…Persistent micropollutants degrade slowly and remain for a longer time in water, air, and/or soil, which makes them more likely to pose a risk to humans and the environment than nonpersistent chemicals . Biodegradation is an important pathway of removal for organic micropollutants in aquatic systems and could determine their environmental persistence. , However, biodegradation is strongly affected by environmental conditions and at present cannot be predicted reliably using physical parameters to characterize the environmental matrix and compound physicochemical properties alone. , …”

Section: Introductionmentioning

confidence: 99%

“…2,3 However, biodegradation is strongly affected by environmental conditions and at present cannot be predicted reliably using physical parameters to characterize the environmental matrix and compound physicochemical properties alone. 4,5 OECD 308 is a standard method for testing aerobic and anaerobic transformation of chemicals in water−sediment systems. 6 Dissipation half-lives (DT50s) obtained through OECD 308 can be compared with regulatory criteria, and therefore OECD 308 is frequently recommended in regulations as a tool to assess persistence (e.g., REACH 7 ).…”

Section: ■ Introductionmentioning

confidence: 99%

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Association between Aquatic Micropollutant Dissipation and River Sediment Bacterial Communities

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Bier

et al. 2020

Environ. Sci. Technol.

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Assessment of micropollutant biodegradation is essential to determine the persistence of potentially hazardous chemicals in aquatic ecosystems. We studied the dissipation half-lives of 10 micropollutants in sediment–water incubations (based on the OECD 308 standard) with sediment from two European rivers sampled upstream and downstream of wastewater treatment plant (WWTP) discharge. Dissipation half-lives (DT50s) were highly variable between the tested compounds, ranging from 1.5 to 772 days. Sediment from one river sampled downstream from the WWTP showed the fastest dissipation of all micropollutants after sediment RNA normalization. By characterizing sediment bacteria using 16S rRNA sequences, bacterial community composition of a sediment was associated with its capacity for dissipating micropollutants. Bacterial amplicon sequence variants of the genera Ralstonia, Pseudomonas, Hyphomicrobium, and Novosphingobium, which are known degraders of contaminants, were significantly more abundant in the sediment incubations where fast dissipation was observed. Our study illuminates the limitations of the OECD 308 standard to account for variation of dissipation rates of micropollutants due to differences in bacterial community composition. This limitation is problematic particularly for those compounds with DT50s close to regulatory persistence criteria. Thus, it is essential to consider bacterial community composition as a source of variability in regulatory biodegradation and persistence assessments.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Association between Aquatic Micropollutant Dissipation and River Sediment Bacterial Communities

Coll

Bier

et al. 2020

Environ. Sci. Technol.

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“…A., & Caminada, D., 2006. Ecotoxicology of human pharmaceuticals.Aquatic toxicology, 76(2),122-159. doi:10.1016/j.aquatox.2005.09.009François, B., Armand, M., Marie-José, D., & Thouand, G. 2016. From laboratory to environmental conditions: a new approach for chemical's biodegradability assessment.EnvironmentalScience and Pollution Research, 23(18),18684-18693. doi:10.1007/s11356- 016-7062-x Fujii, K., & Kikuchi, S., 2005.…”

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confidence: 99%

Occurrence of PPCPs in a Brazilian water reservoir and their removal efficiency by ecological filtration

et al. 2019

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The presence of PPCPs (Pharmaceuticals and Personal Care Products) in water sources and drinking water has concerned researchers in recent times. This study was carried out to evaluate the occurrence of 6 PPCPs (namely paracetamol, diclofenac, naproxen, ibuprofen, benzophenone-3 and methylparaben) in the Lobo reservoir, their degradation products, and how efficienctly they were removed by 22 ecological filters, considering individual and mixtures of compounds. There were 3 spiking events of PPCPs (2 μg L-1) in the ecological filter influents conducted with a lag period of 15 days between spikes. Water sample were collected from the influent and effluent of the filters at 3, 6 and 24 hours after each spiking event. All target PPCPs were identified in the Lobo reservoir water in the range of µg L-1. The personal care products were detected with 100 % frequency in the samples, and in higher concentrations compared to the pharmaceuticals. Degradation products of diclofenac and benzophenone-3 were identified in the water samples. Results of this investigation show that an ecological filter was an effective process (70-99 %) to remove 2 μg L-1 of the selected PPCPs, and demonstrated that the filters were resilient to individual compounds and to their mixtures.

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“…Persistent chemicals, i.e., chemicals recalcitrant to biotic and abiotic transformation, are of concern when entering the aquatic environment as they can distribute widely, reach high concentrations, and induce environmental exposure that is difficult to control and reverse. , Persistence assessment of organic chemicals is therefore a key piece in many international regulatory frameworks. − Yet, professionals in academia, government, and industry involved in the persistence assessment of chemicals have been raising concerns regarding the robustness and reliability of today’s standard procedures to assess a chemical’s potential for biotransformation in the aquatic environment. − …”

Section: Introductionmentioning

confidence: 99%

Biotransformation of Chemicals at the Water–Sediment Interface─Toward a Robust Simulation Study Setup

et al. 2021

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Studying aquatic biotransformation of chemicals in laboratory experiments, i.e., OECD 308 and OECD 309 studies, is required by international regulatory frameworks to prevent the release of persistent chemicals into natural water bodies. Here, we aimed to address several previously described shortcomings of OECD 308/309 studies regarding their variable outcomes and questionable environmental relevance by broadly testing and characterizing a modified biotransformation test system in which an aerated water column covers a thin sediment layer. Compared to standard OECD 308/309 studies, the modified system showed little inter-replicate variability, improved observability of biotransformation, and consistency with first-order biotransformation kinetics for the majority of 43 test compounds, including pharmaceuticals, pesticides, and artificial sweeteners. To elucidate the factors underlying the decreased inter-replicate variability compared to OECD 309 outcomes, we used multidimensional flow cytometry data and a machine learning-based cell type assignment pipeline to study cell densities and cell type diversities in the sediment and water compartments. Our here presented data on cell type composition in both water and sediment allows, for the first time, to study the behavior of microbial test communities throughout different biotransformation simulation studies. We found that sediment-associated microbial communities were generally more stable throughout the experiments and exhibited higher cell type diversity than the water column-associated communities. Consistently, our data indicate that aquatic biotransformation of chemicals can be most robustly studied in test systems providing a sufficient amount of sediment-borne biomass. While these findings favor OECD 308-type systems over OECD 309-type systems to study biotransformation at the water–sediment interface, our results suggest that the former should be modified toward lower sediment–water ratios to improve observability and interpretability of biotransformation.

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From laboratory to environmental conditions: a new approach for chemical’s biodegradability assessment

Cited by 20 publications

References 32 publications

Association between Aquatic Micropollutant Dissipation and River Sediment Bacterial Communities

Association between Aquatic Micropollutant Dissipation and River Sediment Bacterial Communities

Occurrence of PPCPs in a Brazilian water reservoir and their removal efficiency by ecological filtration

Biotransformation of Chemicals at the Water–Sediment Interface─Toward a Robust Simulation Study Setup

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