From Inward Spread of Activation, Active Elongation to the Effect of Organic Calcium Channel Blockers in Muscle Excitation-Contraction Coupling

González‐Serratos, Hugo; Ortega, Alejandro López; Valle-Aguilera, R.; Chang, Ruzhang

doi:10.1007/0-387-24990-7_19

Cited by 3 publications

(1 citation statement)

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“…Gonzalez-Serratos [ 65 ] brought straight fibres into a block of gelatine (length about 2.6 μm). When the sarcomere length was reduced to about 2.0 μm by compressing the gelatine block, the fibre as a whole remained straight but the myofibrils became wavy which confirmed the reversed sliding movement of the filaments [see also 66 ].…”

Section: Resultsmentioning

confidence: 91%

Large-scale Models Reveal the Two-component Mechanics of Striated Muscle

Jarosch¹

2008

IJMS

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This paper provides a comprehensive explanation of striated muscle mechanics and contraction on the basis of filament rotations. Helical proteins, particularly the coiled-coils of tropomyosin, myosin and α-actinin, shorten their H-bonds cooperatively and produce torque and filament rotations when the Coulombic net-charge repulsion of their highly charged side-chains is diminished by interaction with ions. The classical "two-component model" of active muscle differentiated a "contractile component" which stretches the "series elastic component" during force production. The contractile components are the helically shaped thin filaments of muscle that shorten the sarcomeres by clockwise drilling into the myosin cross-bridges with torque decrease (= force-deficit). Muscle stretch means drawing out the thin filament helices off the cross-bridges under passive counterclockwise rotation with torque increase (= stretch activation). Since each thin filament is anchored by four elastic α-actinin Z-filaments (provided with forceregulating sites for Ca 2+ binding), the thin filament rotations change the torsional twist of the four Z-filaments as the "series elastic components". Large scale models simulate the changes of structure and force in the Z-band by the different Z-filament twisting stages A, B, C, D, E, F and G. Stage D corresponds to the isometric state. The basic phenomena of muscle physiology, i. e. latency relaxation, Fenn-effect, the force-velocity relation, the length-tension relation, unexplained energy, shortening heat, the Huxley-Simmons phases, etc. are explained and interpreted with the help of the model experiments.

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Section: Resultsmentioning

confidence: 91%