From hepatoprotection models to new therapeutic modalities for treating liver diseases: a personal perspective

Abstract

A variety of rodent models of hepatoprotection have been developed in which tolerance to acetaminophen-induced hepatotoxicity occurs. Autoprotection/heteroprotection is a phenomenon where prior exposure to a mildly toxic dose of toxicant confers protection against a subsequently administered higher dose of the same toxicant (as in the case of autoprotection) or to a different toxicant (referred to as heteroprotection). Multiple mechanisms regulate this adaptive response, including hepatocellular proliferation, proteostasis, enhanced expression of cytoprotective genes, and altered tissue immune response. In this review, we will discuss recent findings that highlight the complexity of these adaptive mechanisms and we also outline the usefulness of these findings to devise therapeutic and/or diagnostic tools for acetaminophen-induced liver damage in patients.

Antioxidants and Hepato Protective Potentials of Oral Cleome Brachycarpa Hydroalcoholic Extract: An Organ Toxicity Assessment in Mice

“…APAPinduced toxicity is considered as one of the primary causes of acute liver failure; numerous scientific reports have focused majorly on APAP hepatotoxicity. A variety of rodent models of hepatoprotection has been described in which the levels of tolerance to acetaminophen-induced hepatotoxicity could be determined [33]. In fact protection against acetaminophen-induced toxicity has been used as an effective screening test for potential hepatoprotective agents by several investigations [34] which were the major concern of present study.…”