From granuloma to fibrosis in interstitial lung diseases: molecular and cellular interactions

Mornex, Jean‐François; Leroux, Caroline; Greenland, Timothy; Ecochard, D

doi:10.1183/09031936.94.07040779

Cited by 50 publications

(41 citation statements)

References 81 publications

(79 reference statements)

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“…Our present pathological findings (granulomatous nodules development with mild fibrosis) are accompanied by a reduced IL-1b level. These observations are consistent with those found in some chronic lung diseases, such as sarcoidosis, which also showed characteristic lung granuloma formation and low-graded fibrotic changes [26]. However, IL-1b provides a positive signal to fibroblasts [26].…”

Section: Cell and Animal Studies C-k Wang Et Alsupporting

confidence: 81%

“…These observations are consistent with those found in some chronic lung diseases, such as sarcoidosis, which also showed characteristic lung granuloma formation and low-graded fibrotic changes [26]. However, IL-1b provides a positive signal to fibroblasts [26]. Thus, elevated IL-1b levels are frequently associated with lung diseases with extensive interstitial fibrosis, such as idiopathic pulmonary fibrosis [26].…”

Section: Cell and Animal Studies C-k Wang Et Alsupporting

confidence: 79%

“…Thus, a reduction in IL-1b level at this late time period is not totally surprising. It may also be pointed out that there is an interesting inter-relationship between IL-1b levels with granuloma and fibrosis in lung diseases [26]. Our present pathological findings (granulomatous nodules development with mild fibrosis) are accompanied by a reduced IL-1b level.…”

Section: Cell and Animal Studies C-k Wang Et Alsupporting

confidence: 49%

“…This in vitro versus in vivo discrepancy may be explained by the presence of other cell types, such as lymphocytes, in vivo but not in vitro. The release of IL-1b is known to be modulated by lymphocytes [26]. In tt-DDE-exposed lungs, lymphocytic infiltration was prominent in the BAJ lesions.…”

Section: Cell and Animal Studies C-k Wang Et Almentioning

confidence: 90%

“…However, IL-1b provides a positive signal to fibroblasts [26]. Thus, elevated IL-1b levels are frequently associated with lung diseases with extensive interstitial fibrosis, such as idiopathic pulmonary fibrosis [26].…”

Section: Cell and Animal Studies C-k Wang Et Almentioning

confidence: 99%

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Pulmonary changes induced by trans,trans-2,4-decadienal, a component of cooking oil fumes

Wang¹,

Lw²,

Chang³

et al. 2009

European Respiratory Journal

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Cooking oil fumes (COF) are known to be associated with respiratory diseases and risk of lung cancer. Involvement of trans,trans-2,4-decadienal (tt-DDE), a major component in COF, is suspected.Male CD-11 (ICR) mice were intratracheally instilled with either 8 or 24 mg?kg -1 tt-DDE weekly for 8 weeks. Total numbers and types of cells in bronchoalveolar lavage fluid (BALF), as well as pathological changes, and inflammatory gene modulations in the lung tissues were assessed. We demonstrated that the number of alveolar macrophages in the BALF was significantly increased in tt-DDE-exposed animals. Histologically, there was a dose-correlated increase in epithelial hyperplasia and granulomatous nodules at the bronchioloalveolar junctions (BAJ). Although both Clara and alveolar type II cells were present in the BAJ lesion, only Clara cells were actively proliferative. However, only alveolar type II cells were found in the BAJ granulomatous nodules. Enhanced accumulation of phosphorylated signal transducer and activator of transcription 3 (pSTAT3), a known pro-carcinogenic factor, was also detected in many alveolar type II cells at the BAJ lesions.As both BAJ hyperplasia and enhanced pSTAT3 accumulation are known risk factors associated with increased lung adenocarcinoma development, these findings suggest that tt-DDE may pose a risk in lung carcinogenesis.

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Section: Cell and Animal Studies C-k Wang Et Alsupporting

confidence: 81%

Section: Cell and Animal Studies C-k Wang Et Alsupporting

confidence: 79%

Section: Cell and Animal Studies C-k Wang Et Alsupporting

confidence: 49%

Section: Cell and Animal Studies C-k Wang Et Almentioning

confidence: 90%

Section: Cell and Animal Studies C-k Wang Et Almentioning

confidence: 99%

See 3 more Smart Citations

Pulmonary changes induced by trans,trans-2,4-decadienal, a component of cooking oil fumes

Wang¹,

Lw²,

Chang³

et al. 2009

European Respiratory Journal

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DTH-Associated Pathology

Ehlers

Hölscher

2010

Topley &Amp; Wilson's Microbiology and Microbial Infections

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Sarcoidosis

Marcoval,

Mañá

2016

Rook's Textbook of Dermatology, Ninth Edition

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Sarcoidosis is an antigen‐mediated disease of unknown aetiology characterized by the presence of non‐caseating epithelioid cell granulomas in multiple organs. It involves mainly the lungs, mediastinal and peripheral lymph nodes, eyes and skin. Less frequent but usually severe manifestations can occur in the liver, spleen, central nervous system, heart, upper respiratory tract and bones. Cutaneous lesions of sarcoidosis may be specific, showing histopathologically sarcoid granulomas, or non‐specific, mainly erythema nodosum. Cutaneous lesions are frequently the presentation of the disease and skin biopsy enables early diagnosis. Moreover, some types of lesions have prognostic significance and may help to predict the outcome of the systemic disease.

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From granuloma to fibrosis in interstitial lung diseases: molecular and cellular interactions

Abstract: F Fr ro om m g gr ra an nu ul lo om ma a t to o f fi ib br ro os si is s i in n i in nt te er rs st ti it ti ia al l l lu un ng g d di is se ea as se es s: : m mo ol le ec cu ul la ar r a an nd d c ce el ll lu ul la ar r i in nt te er ra ac ct ti io on ns s

Cited by 50 publications

References 81 publications

Pulmonary changes induced by trans,trans-2,4-decadienal, a component of cooking oil fumes

Pulmonary changes induced by trans,trans-2,4-decadienal, a component of cooking oil fumes

DTH-Associated Pathology

Sarcoidosis

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