Abstract:Glycals (carbohydrate enol‐ethers) have enjoyed profound applications in organic synthesis for more than a century. They not only serve as versatile glycosyl donors or as substrates for Ferrier rearrangement, but also find extensive synthetic applications especially as a “chiral pool” for accomplishing the synthesis of a variety of natural and biologically important compounds. As cyclic enol ethers, they demonstrate high reactivity and are among the most and variously transformable monosaccharide derivatives. … Show more
“…46,47 Based on these advantageous properties, many important compounds have been generated from carbohydrates, such as natural occurring polyhydroxypyrrolidine 7-9, therapeutic molecules 10-15, and N-heterocyclic acyclonucleosides 16-18. 48 (Figure 1-16) The improvement of present methodologies and the development of new synthesis routes have led to the accessibility of more N-heterocycle molecules from carbohydrates, such as pyrroles, pyridines, pyrazines, imidazoles, and pyrazoles.…”
“…46,47 Based on these advantageous properties, many important compounds have been generated from carbohydrates, such as natural occurring polyhydroxypyrrolidine 7-9, therapeutic molecules 10-15, and N-heterocyclic acyclonucleosides 16-18. 48 (Figure 1-16) The improvement of present methodologies and the development of new synthesis routes have led to the accessibility of more N-heterocycle molecules from carbohydrates, such as pyrroles, pyridines, pyrazines, imidazoles, and pyrazoles.…”
The chemical technologies for the precision engineering of proteins connect chemistry, biology, and medicine. However, they face enormous hurdles due to a large pool of competing proteinogenic residues. While resolving...
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