From genetic mosaicism to tumorigenesis through indirect genetic effects
Jean‐Pascal Capp,
Francesco Catania,
Frédéric Thomas
Abstract:Genetic mosaicism has long been linked to aging, and several hypotheses have been proposed to explain the potential connections between mosaicism and susceptibility to cancer. It has been proposed that mosaicism may disrupt tissue homeostasis by affecting intercellular communications and releasing microenvironmental constraints within tissues. The underlying mechanisms driving these tissue‐level influences remain unidentified, however. Here, we present an evolutionary perspective on the interplay between mosai… Show more
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