From FDG and beyond: the evolving potential of nuclear medicine

Hirata, Kenji; Kamagata, Koji; Ueda, Daiju; Yanagawa, Masahiro; Kawamura, Mariko; Nakaura, Takeshi; Ito, Rintaro; Tatsugami, Fuminari; Matsui, Yusuke; Yamada, Akira; Fushimi, Yasutaka; Nozaki, Taiki; Fujita, Shohei; Fujioka, Tomoyuki; Tsuboyama, Takahiro; Fujima, Noriyuki; Naganawa, Shinji

doi:10.1007/s12149-023-01865-6

Cited by 5 publications

(1 citation statement)

References 113 publications

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“…The hybrid imaging modality positron emission tomography/computed tomography (PET/CT) not only gives details on morphology and anatomy but also visualizes the physiological and pathological processes within the organs and lesions at the cellular level. 18F-Fluorodeoxyglucose (18F-FDG) is one of the most widely used PET/CT radiotracers [ 1 ]. It is not only used in oncology but also used to detect infective and inflammatory etiology.…”

Section: Introductionmentioning

confidence: 99%

Gallium68-Labeled Fibroblast Activation Protein Inhibitor (68Ga-FAPI) PET/CT as an Alternative to Fluoro18-Fluorodeoxyglucose (18F-FDG) PET/CT: Discussion in a Case of Metastatic Adenocarcinoma of Pancreas

Kumar,

Kumar Upadhyay

et al. 2023

Cureus

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Positron emission tomography (PET) is an integral part of the imaging of solid tumors in today's oncology practice. The most commonly used PET radiotracer is 18F-Fluorodeoxyglucose (18F-FDG). FDG PET has imaging characteristics of a high tumor-to-background uptake ratio and is used in the detection of primary as well as metastatic sites. However, a significant pitfall is its inability to differentiate between neoplastic and infective lesions. To address this concern, many PET radiotracers have been developed and tried over time, a promising one being radiolabelled fibroblast activation protein inhibitor (FAPI). Fibroblast-activated protein (FAP) is a type II transmembrane glycoprotein expressed by cancer-associated fibroblasts (CAFs); it forms a significant component of the tumor stroma. Since there is over-expression of CAF in the majority of malignancies, it is a potential target for molecular imaging using PET. Several radiolabeled FAP inhibitors have been developed for PET imaging of malignancies and have also been used in theranostic applications.

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Section: Introductionmentioning

confidence: 99%