From Electrochemical Biosensors to Biomimetic Sensors Based on Molecularly Imprinted Polymers in Environmental Determination of Heavy Metals

Malitesta, Cosimino; Masi, Sabrina Di; Mazzotta, Elisabetta

doi:10.3389/fchem.2017.00047

Cited by 28 publications

(16 citation statements)

References 30 publications

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“…Removal of the template leaves cavities that are complementary to the original template molecule or its structural analogs in terms of shape, size, and functional group in the resulting polymer. Over the past decades, MIPs have been prepared using various kinds of compounds as templates that had been hard to separate by conventional ways, and they have played important roles in many fields, including solid phase extraction, enantiomer separation, and sensors and membranes . The application of the molecular imprinting technique (MIT) in sample pretreatment has attracted increasing attention because the selectivity of the pretreatment procedure can be improved and the analysis method can be simplified.…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of atrazine molecularly imprinted polymers using acetonitrile and toluene as solvents

Zhang

Kong

et al. 2018

J of Applied Polymer Sci

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Acetonitrile and toluene are solvents commonly used for the synthesis of atrazine molecularly imprinted polymers (MIPs), but their effects have seldom been compared in the same imprinting system. In this paper, effects of the two solvents in an atrazine molecular imprinting system were evaluated theoretically and experimentally. A polarizable continuum model was adopted, and it was found that using the two solvents, the energy difference for the atrazine–methacrylic acid complex between vacuum and solution was not the same. The two types of MIPs prepared using different solvents vary in morphology, porosity, binding capacity, and specificity. All of these results suggest that the abilities of the solvents used to form hydrogen bonds with other compounds in the system are different. The porogen imprinting effect of the solvents also has an influence on binding capacity. Compared to MIPs synthesized using acetonitrile as solvent (MIPs‐ACN), MIPs synthesized using toluene as solvent (MIPs‐PhMe) have fewer but larger pores and exhibit much higher adsorption capability but less rigorous specificity. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47190.

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Section: Introductionmentioning

confidence: 99%

Comparative analysis of atrazine molecularly imprinted polymers using acetonitrile and toluene as solvents

Zhang

Kong

et al. 2018

J of Applied Polymer Sci

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“…Before diving into the reasons behind this dramatic change of the trends, several aspects concerning the use of MIPs as recognition elements in the development of sensors should be summarized. Compared to biological recognition elements, MIPs [34,35,36,37,38,39,40]: (1) are more stable under different chemical, thermal and mechanical conditions; (2) show high performance in the presence of aqueous/organic mixtures or even pure organic solvents; (3) can be considered as “low-cost” materials, as do not require animal experimentation, the template can be recovered and further purified after the synthesis if needed and those cases where extremely toxic and/or expensive reagents are required, templates can be substituted by cheaper and non-harmful analogues; (4) can be prepared even for those compounds for which there are no biological recognition elements available. On the other hand, they: (1) show slower binding kinetics; (2) cannot respond upon binding of non-active optical analytes; (3) should be integrated and coupled to the transducer element, which sometimes is complicated due to the polymeric nature of the material; (4) are limited to the detection of only one analyte hindering simultaneous detection.…”

Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Polymer-Based Hybrid Materials for the Development of Optical Sensors

Rico-Yuste¹,

Carrasco

2019

Polymers

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We report on the development of new optical sensors using molecularly imprinted polymers (MIPs) combined with different materials and explore the novel strategies followed in order to overcome some of the limitations found during the last decade in terms of performance. This review pretends to offer a general overview, mainly focused on the last 3 years, on how the new fabrication procedures enable the synthesis of hybrid materials enhancing not only the recognition ability of the polymer but the optical signal. Introduction describes MIPs as biomimetic recognition elements, their properties and applications, emphasizing on each step of the fabrication/recognition procedure. The state of the art is presented and the change in the publication trend between electrochemical and optical sensor devices is thoroughly discussed according to the new fabrication and micro/nano-structuring techniques paving the way for a new generation of MIP-based optical sensors. We want to offer the reader a different perspective based on the materials science in contrast to other overviews. Different substrates for anchoring MIPs are considered and distributed in different sections according to the dimensionality and the nature of the composite, highlighting the synergetic effect obtained as a result of merging both materials to achieve the final goal.

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“…They are generally used to mimic the natural biological receptors used such as antibodies and enzymes. MIPs offered various advantages such as robust, with high stability, required low‐cost preparation, and great specific recognition ability with a good sensitivity towards the targeted analyte .…”

Section: Introductionmentioning

confidence: 99%

“…Recently, several reviews were published discussing the recent applications in the field of molecularly imprinting polymers . However, there are just a few reports discussing the application of nanomaterials and MIPs in electrochemical sensing strategies .…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Electrochemical Sensors Based on Molecularly Imprinted Polymers and Nanomaterials

2018

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This review focuses on the recent achievement during period of 2013–2018 related to the electrochemical sensors based on molecularly imprinted polymers (MIPs) combined with nanomaterials for various kinds of applications. MIPs based electrochemical sensors have found a great interest due to their high stability, short time required for electropolymerization, and high specificity towards the target analyte. The sensitivity is considered as one of the important parameter in electrochemical sensing strategies that should be improved by the combination of highly conductive nanomaterials with selective MIPs. In general, the most employed nanomaterials are magnetic nanoparticles, gold nanoparticles (AuNPs), carbon nanotubes and graphene. This review discusses the main current achievement as well as the current challenges regarding the development of biomimetic sensors in electroanalysis.

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From Electrochemical Biosensors to Biomimetic Sensors Based on Molecularly Imprinted Polymers in Environmental Determination of Heavy Metals

Cited by 28 publications

References 30 publications

Comparative analysis of atrazine molecularly imprinted polymers using acetonitrile and toluene as solvents

Comparative analysis of atrazine molecularly imprinted polymers using acetonitrile and toluene as solvents

Molecularly Imprinted Polymer-Based Hybrid Materials for the Development of Optical Sensors

Recent Advances in Electrochemical Sensors Based on Molecularly Imprinted Polymers and Nanomaterials

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