From Dysbiosis to Healthy Skin: Major Contributions of Cutibacterium acnes to Skin Homeostasis

Rozas, Miquel; Ruijter, Astrid Hart de; Fábrega, María-José; Zorgani, Amine; Güell, Marc; Paetzold, Bernhard; Brillet, F.

doi:10.3390/microorganisms9030628

Cited by 76 publications

(76 citation statements)

References 148 publications

(95 reference statements)

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“…Therefore, a balance between skin microbes maintains skin homeostasis and an imbalance causes inflammation. Cutibacterium is the most important microbe for skin homeostasis and contributes to the biophysiological functions of the skin via lipid modulation, niche competition, and oxidative stress mitigation [ 32 ]. We observed increased abundances of Cutibacterium and Staphylococcus and a decreased abundance of Corynebacterium in the AGA group, compared to the non-AGA group ( Figure 1 , Supplementary Table S1a ).…”

Section: Discussionmentioning

confidence: 99%

Scalp Microbiome and Sebum Composition in Japanese Male Individuals with and without Androgenetic Alopecia

et al. 2021

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The skin microbiome and sebum may be associated with inflammation-related diseases of the scalp. To assess the pathogenesis and progression of androgenetic alopecia (AGA), we analyzed the composition of sebum and the bacterial and fungal microbiomes of the scalps of 118 Japanese male individuals with and without AGA, then discussed their roles in the pathogenesis of AGA. Sebum triglyceride and palmitic acid contents were higher in the AGA group than in the non-AGA group. Malassezia restricta, a lipophilic fungus that consumes palmitic acid, was abundant on the scalps of patients with AGA. Cutibacterium, Corynebacterium, and Staphylococcus were the most common genera in both groups, and patients with AGA exhibited scalp dysbiosis (increased abundance of Cutibacterium and decreased abundance of Corynebacterium). Our findings suggest that both sebum and the bacterial and fungal microbiomes of the scalp may be involved in the development of AGA.

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Section: Discussionmentioning

confidence: 99%

Scalp Microbiome and Sebum Composition in Japanese Male Individuals with and without Androgenetic Alopecia

et al. 2021

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“…This skin commensal strain is essential for sebum control and maintenance of the acidic pH of the pilosebaceous follicle by hydrolysing sebum triglycerides and via propionic acid secretion [ 4 , 9 ]. However, it can act as a pathogen under dysbiosis conditions that help its overgrowth in active sebaceous glands [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Surface-Modified Multifunctional Thymol-Loaded Biodegradable Nanoparticles for Topical Acne Treatment

et al. 2021

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The present work is focused on the development of novel surface-functionalized poly(lactic-co-glycolic acid) nanoparticles loaded with thymol (TH-NPs) for topical administration enhancing thymol anti-inflammatory, antioxidant and wound healing activities against acne. TH-NPs were prepared by solvent evaporation method using different surface functionalization strategies and obtaining suitable physicochemical parameters and a good short-term stability at 4 °C. Moreover, TH-NPs skin penetration and antioxidant activity were assessed in ex vivo pig skin models. Skin penetration of TH-NPs followed the follicular route, independently of the surface charge and they were able to enhance antioxidant capacity. Furthermore, antimicrobial activity against Cutibacterium acnes was evaluated in vitro by the suspension test showing improved antibacterial performance. Using human keratinocyte cells (HaCat), cytotoxicity, cellular uptake, antioxidant, anti-inflammatory and wound healing activities were studied. TH-NPs were non-toxic and efficiently internalized inside the cells. In addition, TH-NPs displayed significant anti-inflammatory, antioxidant and wound healing activities, which were highly influenced by TH-NPs surface modifications. Moreover, a synergic activity between TH-NPs and their surface functionalization was demonstrated. To conclude, surface-modified TH-NPs had proven to be suitable to be used as anti-inflammatory, antioxidant and wound healing agents, constituting a promising therapy for treating acne infection and associated inflammation.

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“…28 C. acnes, which can be primarily found in the skin microbiome, has been reported to be present in the gastric microbiome. 29 Furthermore, C. acnes can cause lymphocytic gastritis, leading to the production of proinflammatory 31 We also found that the relative abundance of Prevotella nigrescens was significantly higher in healthy controls. A previous study reported that P. nigrescens seems to be more frequently recovered from healthy gingivae as a commensal bacterium.…”

Section: Discussionmentioning

confidence: 57%

“…C . acnes , which can be primarily found in the skin microbiome, has been reported to be present in the gastric microbiome 29 . Furthermore, C .…”

Section: Discussionmentioning

confidence: 99%

Association between bacteria other than Helicobacter pylori and the risk of gastric cancer

et al. 2021

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Background The gastric microbiota, including Helicobacter pylori (HP), has a remarkable role in gastric cancer (GC) occurrence. Evidence for the role of non‐HP bacteria in GC risk is limited. We aimed to observe the association between bacteria other than HP and risk of GC in a Korean population. Methods In this study, 268 GC cases and 288 healthy controls were included. Demographic data and total energy intake data were collected using a general questionnaire and a semiquantitative food frequency questionnaire, respectively. 16S rRNA gene sequencing was performed using DNA extracted from gastric biopsy samples. Results Actinobacteria, Bacteroidetes, Firmicutes, Fusobacteria, and non‐HP Proteobacteria were the five main phyla in the gastric environment. The five phyla were negatively related to the relative abundance of Helicobacter species (all p < 0.001). The Shannon index, richness, and Pilou‐evenness were negatively correlated with Helicobacter species (all p < 0.001), while the microbial dysbiosis index was positively correlated with Helicobacter species (p < 0.001). Participants with a higher relative abundance of Actinobacteria species showed a significantly increased risk of GC (OR: 3.16, 95% CI = 1.92–5.19, p‐trend<0.001). The non‐HP microbiota composition among the four groups (HP+cases, HP‐ cases, HP+controls, and HP‐ controls) was significantly different (ANOSIM R = 0.10, p = 0.001). Conclusion Other than HP, several bacterial species might be associated with GC risk. HP status and GC status could determine the differences in microbial compositions. Further large prospective studies are warranted to confirm our findings.

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From Dysbiosis to Healthy Skin: Major Contributions of Cutibacterium acnes to Skin Homeostasis

Cited by 76 publications

References 148 publications

Scalp Microbiome and Sebum Composition in Japanese Male Individuals with and without Androgenetic Alopecia

Scalp Microbiome and Sebum Composition in Japanese Male Individuals with and without Androgenetic Alopecia

Surface-Modified Multifunctional Thymol-Loaded Biodegradable Nanoparticles for Topical Acne Treatment

Association between bacteria other than Helicobacter pylori and the risk of gastric cancer

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