From Density to Structure: Growing Up and Growing Old on the Surfaces of Bone

Seeman, Ego

doi:10.1359/jbmr.1997.12.4.509

Cited by 278 publications

(176 citation statements)

References 78 publications

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“…At present, most evaluations of change in bone size in humans are small and cross-sectional and are subject to limited power and cohort effects, 69,77,106,107 but some longitudinal studies support the increase in bone size with age. 12,13,69 Mechanical events have usually been assumed to underlie the observation that bone size can increase in adults.…”

Section: Periosteal Bone Formation In Adulthoodmentioning

confidence: 99%

RETRACTED: The periosteum

Augustin¹,

Antabak²,

Davila³

2007

Injury

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Section: Periosteal Bone Formation In Adulthoodmentioning

confidence: 99%

RETRACTED: The periosteum

Augustin¹,

Antabak²,

Davila³

2007

Injury

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“…Rather, it derives the areal BMD (aBMD; gm/cm 2 ) by dividing the bone mineral content by the projected area. As such, it is not sensitive to size differences in the third dimension (8) and may lead to erroneous conclusions (9).…”

mentioning

confidence: 99%

Tibial subchondral trabecular volumetric bone density in medial knee joint osteoarthritis using peripheral quantitative computed tomography technology

Bennell¹,

Creaby²,

Wrigley³

et al. 2008

Arthritis & Rheumatism

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Objective. Knee osteoarthritis (OA) is an organlevel failure of the joint involving pathologic changes in articular cartilage and bone. This cross-sectional study compared apparent volumetric bone mineral density (vBMD) of proximal tibial subchondral trabecular bone in people with and without knee OA, using peripheral quantitative computed tomography (pQCT).Methods. Seventy-five individuals with mild or moderate medial compartment knee OA and 41 asymptomatic controls were recruited. Peripheral QCT was used to measure vBMD of trabecular bone beneath medial and lateral tibiofemoral compartments at levels of 2% and 4% of tibial length, distal to the tibial plateau.Results. There was no significant difference in vBMD beneath the overall medial and lateral compartments between the 3 groups. However, in the affected medial compartment of those with moderate OA, lower vBMD was seen in the 2 posterior subregions compared with controls and those with mild knee OA, while higher vBMD was seen in the anteromedial subregion. Beneath the unaffected or lesser affected lateral compartment, significantly lower vBMD was seen at the 2% level in the anterior and lateral subregions of those with moderate disease. Volumetric BMD ratios showed relatively higher vBMD in the medial compartment compared with the lateral compartment, but these ratios were not influenced by disease status.Conclusion. Subregional vBMD changes were evident beneath the medial and lateral compartments of those with moderate medial knee OA. Of import, the posterior subchondral trabecular regions of the medial tibial plateau have markedly lower vBMD.

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“…There are numerous microstructural features within bone that contribute to its overall strength and ability to withstand mechanical forces. Understanding how they interact with one another will enhance our knowledge of bone biology (Seeman 1997). Although our method has already produced useful results, we shall continue to address some important analytical issues.…”

Section: Discussionmentioning

confidence: 98%

Untitled

2000

Scanning

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Summary: Detailed studies of biological phenomena often involve multiple microscopy and imaging modes and media. For bone biology, various forms of light and electron microscopy are used to study the microscopic structure of bone. Integrating information from the different sources is necessary to understand how different aspects of the bone structure interact. To accomplish this, methods were developed to prepare and image thin sections for correlative light microscopy (LM) and backscattered electron imaging in the scanning electron microscope (BSE-SEM). Images of the same fields of view may then be analyzed for degrees of relationships between specimen features not observed by LM or SEM alone. These methods are applied here to study possible associations between the degree of bone mineralization and pattern of collagen fiber orientation in the mid-shaft of the human femur. The "relational images" obtained allow us to examine the relationship between these two variables, both objectively and quantitatively.

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From Density to Structure: Growing Up and Growing Old on the Surfaces of Bone

Cited by 278 publications

References 78 publications

RETRACTED: The periosteum

RETRACTED: The periosteum

Tibial subchondral trabecular volumetric bone density in medial knee joint osteoarthritis using peripheral quantitative computed tomography technology

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