From dengue to Zika: the wide spread of mosquito-borne arboviruses

Sukhralia, Shivani; Verma, Mansi; Gopirajan, Shruthi; Dhanaraj, Premnath; Lal, Rup; Mehla, Neeti; Kant, Chhaya Ravi

doi:10.1007/s10096-018-3375-7

Cited by 53 publications

(24 citation statements)

References 90 publications

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“…Combined with climate change, increased global transportation, deforestation in response to increased population density, human encroachment on wild habitats, and viral genome evolution, global distribution has been extensive and rapid in recent times [ [4] , [5] , [6] ]. Autochthonous vector-borne occurrences of CHIKV, DENV, and ZIKV, have been reported in 111,152 and 79 countries or territories respectively [ 7 ] with up to 123 countries or territories reporting more than one arboviral disease [ 3 ]. The three arboviruses have clinical similarities, exhibiting a short incubation period of 3–10 days and overlapping clinical features such as fever, maculopapular rash, myalgia, arthralgia, and retro-orbital pain.…”

Section: Introductionmentioning

confidence: 99%

“…Spontaneous mutation in the gene coding for Non-Structural Protein 1 (NS1) enhanced infectivity of the Asian lineage of ZIKV which may explain the 50% symptomatology compared with the African and South American lineages [ 7 , 14 , 15 ]. Innate immunity, ADE from previous flavivirus exposure and host immune response are key regulators of neuropathology.…”

Section: Introductionmentioning

confidence: 99%

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Vertically transmitted chikungunya, Zika and dengue virus infections

Evans-Gilbert

2020

International Journal of Pediatrics and Adolescent Medicine

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Chikungunya (CHIKV), Zika (ZIKV), and Dengue viruses (DENV) exhibit similar epidemiological and clinical patterns but have different pathophysiological mechanisms of disease manifestations. Differences occur in the severity of clinical presentations with the highest mortality in the general population attributed to DENV and neurological morbidity due to ZIKV. ZIKV and DENV infections can cause fetal loss with ZIKV exhibiting teratogenesis. CHIKV is associated with severe complications in the newborn. Co-circulation of the three viruses and the cross-reactive immune response between ZIKV and DENV viruses has implications for an attenuated clinical response and future vaccine development. Co-infections could increase due to the epidemiologic synergy, but there is limited evidence about the clinical effects, especially for the vulnerable newborn. The purpose of this paper is to review the pathophysiological basis for vertically transmission manifestations due to CHIKV, DENV, and ZIKV, to determine the potential effects of co-circulation on newborn outcomes and the potential for vaccine protection. Inflammatory cytokines are responsible for placental breaches in DENV and ZIKV; Hofbauer cells facilitate the transfer of ZIKV from the placenta to the fetal brain, and high viral loads and mechanical placental disruption facilitate the transmission of CHIKV. Co-infection of these viruses can present with severe manifestations, but the clinical and serologic evidence suggests that one virus predominates which may influence fetal transmission. All three viruses are in different stages of vaccine development with DENV vaccine being fully licensed. Antibody-enhanced infections in seronegative vaccinated candidates who develop natural infection to dengue limit its use and have implications for ZIKV vaccine development. Targeting transmission capacity in the vector could prevent transmission to all three viruses, and breast milk immunity could provide further clues for vaccine development.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vertically transmitted chikungunya, Zika and dengue virus infections

Evans-Gilbert

2020

International Journal of Pediatrics and Adolescent Medicine

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“…Dengue virus (DENV) is member of the genus Flavivirus in the family Flaviviridae . Currently, it has emerged as the most prevalent arthropod‐borne virus and is recognized as a serious public health problem, especially in the tropics and subtropics . Dengue is caused by any one of the four serotypes of DENV (DENV1‐4) that are characterized by distinct phylogenetic and antigenic properties and is transmitted by the hematophagous mosquitoes Aedes aegypti and Aedes albopictus.…”

Section: Introductionmentioning

confidence: 99%

Serum lipid profile as a predictor of dengue severity: A systematic review and meta‐analysis

Lima

Souza

Fernandes

et al. 2019

Reviews in Medical Virology

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Summary Dengue virus is known to modulate host cell lipid metabolism in order to promote efficient viral replication. Recent studies have focused on circulating lipids as potential biomarkers of dengue severity; however, the results obtained so far lack the consistency to establish a definite relationship between the two. Therefore, in the present study, we investigated serum lipids as potential biomarkers of dengue severity by conducting a meta‐analysis of the currently available clinical data. Nine studies that evaluated 1,953 patients were included in the review, many of which were cross‐sectional (44.4%) and conducted in Asian countries (55.5%). These studies observed the presence of lipids in serum samples (77%) of patients in the acute phase of the disease (88.8%). Circulating total‐cholesterol (P = .001) and LDL (P = .001) levels, but not HDL (P = .07), VLDL (P = .9) and triglyceride (P = .57) levels, were inversely and significantly correlated with dengue severity. Total cholesterol (P ≤ .001) and LDL (P = .001) were also useful in determining the risk of hypovolemic shock in patients with severe dengue. Subgroup analysis showed that factors, such as design (cross‐sectional vs cohort), racial‐ethnic differences (Asian vs Latin Americans), and age range (children vs adult) influenced the correlation and also contributed to the high level of heterogeneity in the studies. Our meta‐analysis demonstrates that total‐cholesterol and LDL‐cholesterol levels should be explored as routine laboratory markers for dengue severity, as they will help in employing an appropriate patient therapy, and thus optimize the use of available resources.

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“…Dengue virus or as commonly called DENV is a single stranded RNA virus that infects approximately 390 million people each year (Achee et al, 2015), putting more than two-fifth of the world's population under the threat of this efficacious virus. The dengue fever has, thus become one of the most widespread disease (Sukhralia et al, 2018). The virus belongs to the family Flaviviridae and genus Flavivirus (Westaway et al, 1985;Back and Lundkvist, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…DENV is an arbovirus, having two known mosquito vectors Aedes aegypti (Gratz, 1999) and Aedes albopictus (Lambrechts et al, 2010). The positive stranded RNA genome of dengue virus is of 10.7 Kb size and composed of three structural proteins (Envelope, Capsid, Membrane) and seven nonstructural proteins (NS1, NS2A, NS2B,NS3, NS4A, NS4B, NS5) (Imrie et al, 2010;Guzman et al, 2010;Sukhralia et al, 2018). There are atleast four serotypes and they show 65% similarity in the genome structure (Azhar et al, 2015;Ramanathan et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Highly conserved epitopes of DENV structural and non-structural proteins: Candidates for universal vaccine targets

Verma

Bhatnagar

Kumari

et al. 2019

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A B S T R A C TDengue is a severe emerging arthropod borne viral disease occurring globally. Around two fifths of the world's population, or up to 3.9 billion people, are at a risk of dengue infection. Infection induces a life-long protective immunity to the homologous serotype but confers only partial and transient protection against subsequent infection caused by other serotypes. Thus, there is a need for a vaccine which is capable of providing a life-long protection against all the serotypes of dengue virus.In our study, comparative genomics of Dengue virus (DENV) was conducted to explore potential candidates for novel vaccine targets. From our analysis we successfully found 100% conserved epitopes in Envelope protein (RCPTQGE); NS3 (SAAQRRGR, PGTSGSPI); NS4A (QRTPQDNQL); NS4B (LQAKATREAQKRA) and NS5 proteins (QRGSGQV) in all DENV serotypes. Some serotype specific conserved motifs were also found in NS1, NS5, Capsid, PrM and Envelope proteins. Using comparative genomics and immunoinformatics approach, we could find conserved epitopes which can be explored as peptide vaccine candidates to combat dengue worldwide. Serotype specific epitopes can also be exploited for rapid diagnostics. All ten proteins are explored to find the conserved epitopes in DENV serotypes, thus making it the most extensively studied viral genome so far.

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From dengue to Zika: the wide spread of mosquito-borne arboviruses

Cited by 53 publications

References 90 publications

Vertically transmitted chikungunya, Zika and dengue virus infections

Vertically transmitted chikungunya, Zika and dengue virus infections

Serum lipid profile as a predictor of dengue severity: A systematic review and meta‐analysis

Highly conserved epitopes of DENV structural and non-structural proteins: Candidates for universal vaccine targets

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