SummaryBackground: Founded in 1962 and, therefore, the oldest international journal in medical informatics, Methods of Information in Medicine will publish its 50th volume in 2011. At the start of the journal's sixth decade, a discussion on the journal's profile seems appropriate. Objectives: To report on the new opportunities for online access to Methods publications as well as on the recent strategic decisions regarding the journal's aims and editorial policies. Methods: Describing and analyzing the journal's aims and scope. Reflecting on recent publications and on the journal's development during the last decade.