From Classical to Unconventional: The Immune Receptors Facilitating Platelet Responses to Infection and Inflammation

Gautam, Iluja; Storad, Zachary A; Filipiak, Louis; Huss, Chadwick; Meikle, Claire K.; Worth, Randall G.; Wuescher, Leah M.

doi:10.3390/biology9100343

Cited by 9 publications

(16 citation statements)

References 186 publications

(254 reference statements)

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“…They contain mitochondria, mRNA, and all the translational machinery needed for protein synthesis (approximately 5000 different proteins are present inside platelets 7 ), including the ribosomes, endoplasmic reticulum, and Golgi apparatus. They host several types of storage granules containing a wide array of potentially active molecules (fibrinogen, growth factors, cytokines, chemokines, adenosine diphosphate [ADP], and serotonin), 8 and they secrete a myriad of membrane vesicles (both exosomes and microvesicles) into the blood that together represent the majority of circulating vesicles 9 . Moreover, platelets have adhesion and immune receptors 10,11 .…”

Section: Iron and Platelets: General Aspectsmentioning

confidence: 99%

Iron and platelets: A subtle, under‐recognized relationship

et al. 2021

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Section: Iron and Platelets: General Aspectsmentioning

confidence: 99%

Iron and platelets: A subtle, under‐recognized relationship

et al. 2021

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“…Among the multitude of substances released, microbicide molecules such as peptides and cytokines are present, which confer antiviral activity to the platelets, helping inactivate and eliminate the virus [29]. This platelet degranulation and consequent release of molecules also generate an indirect response against infection, involving cells of the immune system [30][31][32][33]. 1, different responses are triggered.…”

Section: Role Of Platelets Against Viral Infections and Sars-cov-2mentioning

confidence: 99%

Platelet Lysate Nebulization Protocol for the Treatment of COVID-19 and Its Sequels: Proof of Concept and Scientific Rationale

Beitia¹,

Delgado²,

Sánchez³

et al. 2021

IJMS

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One of the most severe effects of coronavirus disease 2019 (COVID-19) is lung disorders such as acute respiratory distress syndrome. In the absence of effective treatments, it is necessary to search for new therapies and therapeutic targets. Platelets play a fundamental role in respiratory disorders resulting from viral infections, being the first line of defense against viruses and essential in maintaining lung function. The direct application of platelet lysate (PL) obtained from the platelet-rich plasma of healthy donors could help in the improvement of the patient due its anti-inflammatory, immunomodulatory, antifibrotic, and repairing effects. This work evaluates PL nebulization by analyzing its levels of growth factors and its biological activity on lung fibroblast cell cultures, besides describing a scientific basis for its use in this kind of pathology. The data of the work suggest that the molecular levels and biological activity of the PL are maintained after nebulization. Airway administration would allow acting directly on the lung tissue modulating inflammation and stimulating reparative processes on key structures such as the alveolocapillary barrier, improving the disease and sequels. The protocol developed in this work is a first step for the study of nebulized PL both in animal experimentation and in clinical trials.

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“…Namely, Scavenger receptors (SR) are expressed on the surface of platelets, and these receptors are characterized by the ability to recognize native or oxidized forms of various lipoproteins. Receptor classes SR-BI and CD36 have the largest role in lipid/lipoprotein metabolism [ 63 ]. CD36 (cluster of differentiation 36; glycoprotein IV or glycoprotein IIIb) receptors are present on the membranes of many cells, including platelets.…”

Section: High-density Lipoprotein (Hdl) and Discontinuation Of P2ymentioning

confidence: 99%

Lipids and Antiplatelet Therapy: Important Considerations and Future Perspectives

Ðukanović

Obradović

Zdravković

et al. 2021

IJMS

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Lipids play an essential role in platelet functions. It is known that polyunsaturated fatty acids play a role in increasing platelet reactivity and that the prothrombotic phenotype plays a crucial role in the occurrence of major adverse cardiovascular events. The ongoing increase in cardiovascular diseases’ incidence emphasizes the importance of research linking lipids and platelet function. In particular, the rebound phenomenon that accompanies discontinuation of clopidogrel in patients receiving dual antiplatelet therapy has been associated with changes in the lipid profile. Our many years of research underline the importance of reduced HDL values for the risk of such a rebound effect and the occurrence of thromboembolic events. Lipids are otherwise a heterogeneous group of molecules, and their signaling molecules are not deposited but formed “on-demand” in the cell. On the other hand, exosomes transmit lipid signals between cells, and the profile of such changes can be monitored by lipidomics. Changes in the lipid profile are organ-specific and may indicate new drug action targets.

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From Classical to Unconventional: The Immune Receptors Facilitating Platelet Responses to Infection and Inflammation

Cited by 9 publications

References 186 publications

Iron and platelets: A subtle, under‐recognized relationship

Iron and platelets: A subtle, under‐recognized relationship

Platelet Lysate Nebulization Protocol for the Treatment of COVID-19 and Its Sequels: Proof of Concept and Scientific Rationale

Lipids and Antiplatelet Therapy: Important Considerations and Future Perspectives

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