From classical taxonomy to genome and metabolome: Towards comprehensive quality standards for medicinal herb raw materials and extracts

Govindaraghavan, Suresh; Hennell, James R.; Sucher, Nikolaus J.

doi:10.1016/j.fitote.2012.05.001

Cited by 31 publications

(38 citation statements)

References 50 publications

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“…Three critical steps at the very beginning of the manufacturing process are: 1) cultivation/collection of authentic whole plants or plant parts, 2) sorting, drying and powdering of the herbal material, and, 3) non-targeted or targeted, solvent(s) based extractions of the herbal materials to enrich or to include 'active' or 'marker' compounds [47]. Any compromise in quality in each of these steps will permeate the sequential links in the manufacturing process.…”

Section: Discussionmentioning

confidence: 99%

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Quality and Efficacy of Tribulus terrestris as an Ingredient for Dermatological Formulations

Sansebastiano¹,

Benedictis²,

Carati³

et al. 2013

TODJ

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Tribulus terrestris L. (Zygophyllaceae) is an annual plant commonly known as Puncture vine. It is dramatically gaining interest as a rich source of saponins. T. terrestris is a promising ingredient for many industries and recent patents on dermatological applications support the use of this plant for cosmetics and hygiene. Nonetheless problems arise in the selection of the material to be used. The extracts of different origins may differ substantially. Natural speciation processes normally influence 'variations' in wild-crafted medicinal plants. The genus Tribulus is emblematic. Taxonomic status of T. terrestris is complicated by the wide geographical distribution leading to high levels of genetic polymorphism. Being aware of such variability we selected 3 commercial Tribulus extracts and compared their biological effect on Candida albicans with the effect produced by an extract from local plants (South of Apulia, Italy). One of the commercial extracts with the best anti-candida performance was used to substitute triclosan in a detergent formulation and it proved to improve the product performance in the control of potentially pathogenic skin flora such as C. albicans.

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Section: Discussionmentioning

confidence: 99%

“…High levels of genetic polymorphism have been demonstrated in T. terrestris populations collected within the Indian sub-continent [50]. Fluctuating content of various saponins has been demonstrated within species, geographic distribution and spatiotemporal variation [47].…”

Section: Discussionmentioning

confidence: 99%

Quality and Efficacy of Tribulus terrestris as an Ingredient for Dermatological Formulations

Sansebastiano¹,

Benedictis²,

Carati³

et al. 2013

TODJ

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“…Hundreds of thousands of herbal products are commercially available across the world that practitioners can prescribe and users self-prescribe. For many of these products it is difficult to assess their quality because there are no agreed international regulations for standardising the cultivation, authentication, profiling and naming of medicinal plants; and reporting on the processing and extraction methods used 7,11,12 .…”

Section: Quality Issues With Herbal Productsmentioning

confidence: 99%

Applying evidence-based-medicine to the prescribing of herbal products

Hunter¹

2013

OA Alternative Medicine

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“…The use of authentic medicinal plant species is a fundamental requirement in herbal medicine (Govindaraghavan et al 2012). Adulteration, substitution, and mislabelling may reduce the efficacy of the herbal drugs and also cause potential side effects to the patients (Newmaster et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Development of Chemical Fingerprints to Differentiate the Controversial Indian Herbal Drugs Eclipta Prostrata and Wedelia Calendulacea (Bhringraja)

Vadivel¹,

Anand²,

Monajkumar³

et al. 2017

Bull. Pharm. Res.

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In Indian system of medicine, Eclipta prostrata is an important herbal ingredient of several Ayurvedic and Siddha formulations and it is commonly called as Bhringraja. But, this plant is often confused with Wedelia calendulacea, which is also known as Bhringraja and also being adulterated in Indian herbal market. In order to differentiate these plant drugs (Eclipta prostrata and Wedelia calendulacea), in the present work we have developed chemical fingerprints. Phytochemical analysis, UV-Visible, FT-IR and NMR spectroscopy, HPTLC and HPLC chromatography were carried out in the selected plant materials. Phytochemical analysis of methanolic extract of investigated materials showed that W. calendulacea contained higher level of total phenolic compounds (381.82 mg GAE/100 g) when compared to E. prostrata (105 mg GAE/100 g). Scanning in UV-Visible spectroscopy exhibited difference between selected samples, especially at 250-450 nm. Similarly, FT-IR spectroscopy of raw materials indicated notable difference between the samples at 400 -1000 cm -1 region. NMR spectroscopy illustrated remarkable difference between the chloroform extract of selected samples at 1-2 ppm region. HPTLC profile of methanolic extract of E. prostrata exhibited a total number of 9 peaks while W. calendulacea showed 12 number of peaks. Chemical profile investigated in the present study would be helpful to differentiate E. prostrata from W. calendulacea and also useful to prevent their adulteration in herbal industry.

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From classical taxonomy to genome and metabolome: Towards comprehensive quality standards for medicinal herb raw materials and extracts

Cited by 31 publications

References 50 publications

Quality and Efficacy of Tribulus terrestris as an Ingredient for Dermatological Formulations

Quality and Efficacy of Tribulus terrestris as an Ingredient for Dermatological Formulations

Applying evidence-based-medicine to the prescribing of herbal products

Development of Chemical Fingerprints to Differentiate the Controversial Indian Herbal Drugs Eclipta Prostrata and Wedelia Calendulacea (Bhringraja)

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