From cellular to fear memory: An epigenetic toolbox to remember

Coda, Davide Martino; Gräff, Johannes

doi:10.1016/j.conb.2023.102829

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2024

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Cited by 3 publications

References 89 publications

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Neuroepigenetic Editing

Hamilton,

Lim,

Nestler

et al. 2024

Methods in Molecular Biology

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Neuroepigenetic Editing

Hamilton,

Lim,

Nestler

et al. 2024

Methods in Molecular Biology

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Editorial overview: Introduction to neurobiology of disease

Musiek,

Nestler

2024

Current Opinion in Neurobiology

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Targeting neuronal epigenomes for brain rejuvenation

Zocher

2024

EMBO J

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Aging is associated with a progressive decline of brain function, and the underlying causes and possible interventions to prevent this cognitive decline have been the focus of intense investigation. The maintenance of neuronal function over the lifespan requires proper epigenetic regulation, and accumulating evidence suggests that the deterioration of the neuronal epigenetic landscape contributes to brain dysfunction during aging. Epigenetic aging of neurons may, however, be malleable. Recent reports have shown age-related epigenetic changes in neurons to be reversible and targetable by rejuvenation strategies that can restore brain function during aging. This review discusses the current evidence that identifies neuronal epigenetic aging as a driver of cognitive decline and a promising target of brain rejuvenation strategies, and it highlights potential approaches for the specific manipulation of the aging neuronal epigenome to restore a youthful epigenetic state in the brain.

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From cellular to fear memory: An epigenetic toolbox to remember

Cited by 3 publications

References 89 publications

Neuroepigenetic Editing

Neuroepigenetic Editing

Editorial overview: Introduction to neurobiology of disease

Targeting neuronal epigenomes for brain rejuvenation

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