From black to white: A roadmap to containing the rise of candidiasis amidst COVID-19 and mucormycosis in India

Nawaz, Faisal A.; Yaqoob, Sadia; Sharma, Ashish; Khan, Adil Aziz; Rackimuthu, Sudhan; Ghazi, Behram Khan; Khawaja, Uzzam Ahmed; Essar, Mohammad Yasir

doi:10.1016/j.cegh.2021.100917

Cited by 1 publication

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Though at the outset it appeared as if the corticosteroid therapy increased the incidence of fungal infections in India, 4,5 we are uncertain about the actual frequency of fungal infections and their risk factors in these Indian patients with COVID-19. There are very few studies from India showing the type of fungal infections.…”

Section: Introductionmentioning

confidence: 99%

Corticosteroids and invasive fungal infections in hospitalized COVID-19 patients – A single-center cross-sectional study

Ramanathan,

Pari Thenmozhi,

Singh

et al. 2023

F1000Res

View full text Add to dashboard Cite

Background: During the coronavirus disease 2019 (COVID-19) epidemic, an increase in the incidence of fungal infections was observed. However, the real magnitude of these fungal infections and their risk factors among COVID-19 patients in the Indian population is unknown. Aim: To study the frequency, and spectrum of invasive fungal infections (IFI) among hospitalized COVID-19 patients, and the risk factors associated with invasive fungal infections. Methods: We performed a retrospective, cross-sectional study; including all adult patients, admitted to Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), a tertiary care hospital in Southern India between April 2020 and August 2021, with COVID-19. Based on clinical-radiological features, patients with fungal infections were grouped into three diagnostic categories. Demographics, clinical, and laboratory features of patients with fungal infections were analyzed to identify the risk factors. Results: About 10% (449 out of 4650) of the admitted patients with recent COVID-19, had some form of IFI. Among the patients with IFI, 80% (366 out of 449) were hospitalized for active COVID-19, whereas almost all the patients admitted with post-COVID complications had IFI. Of the 449 patients with IFI, 377 had mold infections and 88 had invasive candidiasis. Mucormycosis was the most common mold infection. Diabetes and diabetic ketoacidosis were strong independent predictors of IFI. We also found an association between end-stage renal disease, central venous catheterization, antibiotic usage, prior stroke, and corticosteroid therapy with IFI. Conclusions: The frequency of fungal infections among hospitalized COVID-19 patients was high. Special precautions in COVID-19 patients with diabetes mellitus, corticosteroid therapy, and prior antibiotic usage may help to reduce invasive fungal infections.

show abstract

Section: Introductionmentioning

confidence: 99%