From bench to bedside: Current developments and future possibilities of artificial human ovary to restore fertility

Salama, Mahmoud; Woodruff, Teresa K.

doi:10.1111/aogs.13552

Cited by 28 publications

(28 citation statements)

References 50 publications

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“…Although successful only in mice [200,201], further advances in research will improve artificial ovary results and help to establish it for transposition to human models [202,203]. Recently, our coauthors Salama and Woodruff have published a new article that discusses in detail the concept of artificial human ovary and its clinical applications from bench to bedside [204].…”

Section: Experimental Optionsmentioning

confidence: 99%

Preserving fertility in female patients with hematological malignancies: a multidisciplinary oncofertility approach

2019

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Oncofertility is a new interdisciplinary field at the intersection of oncology and reproductive medicine that expands fertility options for young cancer patients. The most common forms of hematological malignancies that occur in girls and young women and therefore necessitate oncofertility care are acute lymphocytic leukemia, acute myeloid leukemia, non-Hodgkin's lymphoma, and Hodgkin's lymphoma. Aggressive gonadotoxic anticancer regimens including alkylating chemotherapy and total body irradiation are used often in treating girls and young women with hematological malignancies. The risks of gonadotoxicity and subsequent iatrogenic premature ovarian insufficiency and fertility loss depend mainly on the type and stage of the disease, dose of anticancer therapy as well as the age of the patient at the beginning of treatment. To avoid or at least mitigate the devastating complications of anticancer therapy-induced gonadotoxicity, effective and comprehensive strategies that integrate different options for preserving and restoring fertility ranging from established to experimental strategies should be offered before, during, and after chemotherapy or radiotherapy. A multidisciplinary approach that involves strong coordination and collaboration between hemato-oncologists, gynecologists, reproductive biologists, research scientists, and patient navigators is essential to guarantee high standard of care.

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Section: Experimental Optionsmentioning

confidence: 99%

Preserving fertility in female patients with hematological malignancies: a multidisciplinary oncofertility approach

2019

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“…After complete cure from cancer, a new assessment of reproductive functions should be performed. If anticancer therapy induced gonadal dysfunction persists, fertility restoration may be achieved by using stored gametes or gonadal tissue [17][18][19][20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Installing oncofertility programs for common cancers in limited resource settings (Repro-Can-OPEN Study): An extrapolation during the global crisis of Coronavirus (COVID-19) pandemic

Salama

Ataman

Braham³

et al. 2020

J Assist Reprod Genet

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Purpose The state of limited resource settings that Coronavirus (COVID-19) pandemic has created globally should be taken seriously into account especially in healthcare sector. In oncofertility, patients should receive their fertility preservation treatments urgently even in limited resource settings before initiation of anticancer therapy. Therefore, it is very crucial to learn more about oncofertility practice in limited resource settings such as in developing countries that suffer often from shortage of healthcare services provided to young patients with cancer. Methods As an extrapolation during the global crisis of COVID-19 pandemic, we surveyed oncofertility centers from 14 developing countries (

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“…Artificial ovary is an experimental method to obtain mature oocytes by an ex vivo multistep procedure involving in vitro cultures of ovarian tissue, follicles, and oocytes [ 122 ]. According to previous research, ovarian follicles and their enclosed oocytes can be harvested before or after ovarian tissue freezing and thawing [ 123 , 124 , 125 , 126 , 127 , 128 , 129 ].…”

Section: Fertility Preservation Optionsmentioning

confidence: 99%

Advances in the Treatment and Prevention of Chemotherapy-Induced Ovarian Toxicity

Cho

Lee

Min

et al. 2020

IJMS

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Due to improvements in chemotherapeutic agents, cancer treatment efficacy and cancer patient survival rates have greatly improved, but unfortunately gonadal damage remains a major complication. Gonadotoxic chemotherapy, including alkylating agents during reproductive age, can lead to iatrogenic premature ovarian insufficiency (POI), and loss of fertility. In recent years, the demand for fertility preservation has increased dramatically among female cancer patients. Currently, embryo and oocyte cryopreservation are the only established options for fertility preservation in women. However, there is growing evidence for other experimental techniques including ovarian tissue cryopreservation, oocyte in vitro maturation, artificial ovaries, stem cell technologies, and ovarian suppression. To prevent fertility loss in women with cancer, individualized fertility preservation options including established and experimental techniques that take into consideration the patient’s age, marital status, chemotherapy regimen, and the possibility of treatment delay should be provided. In addition, effective multidisciplinary oncofertility strategies that involve a highly skilled and experienced oncofertility team consisting of medical oncologists, gynecologists, reproductive biologists, surgical oncologists, patient care coordinators, and research scientists are necessary to provide cancer patients with high-quality care.

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From bench to bedside: Current developments and future possibilities of artificial human ovary to restore fertility

Cited by 28 publications

References 50 publications

Preserving fertility in female patients with hematological malignancies: a multidisciplinary oncofertility approach

Preserving fertility in female patients with hematological malignancies: a multidisciplinary oncofertility approach

Installing oncofertility programs for common cancers in limited resource settings (Repro-Can-OPEN Study): An extrapolation during the global crisis of Coronavirus (COVID-19) pandemic

Advances in the Treatment and Prevention of Chemotherapy-Induced Ovarian Toxicity

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