From bench to bedside: Biosensing strategies to evaluate endocrine disrupting compounds based on epigenetic events and their potential use in medicine

Endocrine-disrupting pollutants properties affecting their bioactivity, remediation, and detection

“…Given the long-term persistence and high bioaccumulation tendency of ED pollutants, several efforts are devoted to establish highly selective and sensitive analytical approaches for the detection of trace amounts of such contaminants, in order to support and complement classical methods based on chromatography and mass spectrometry. Recent advances in the development of specific sensors and biosensors, as well as in the application of nanostructured materials (e.g., metal-organic frameworks, molecular imprinted polymers, carbon nanotubes, graphene, polymer nanocomposites, metal oxides, quantum dots) to the detection of EDCs in different sample matrices have been extensively reviewed [12][13][14][15][16]. In this context, understanding the molecular basis of recognition of suspected EDCs by their biological targets, might help the design of novel biomimetic platforms for sensing ED pollutants.…”