From bench to bedside? Biomedical scientists’ expectations of stem cell science as a future therapy for diabetes

Wainwright, Steven P.; Williams, Curtis A.; Michael, Mike; Farsides, Bobbie; Cribb, Alan

doi:10.1016/j.socscimed.2006.05.003

Cited by 96 publications

(106 citation statements)

References 25 publications

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“…In our example, the technological devices for molecular measurement and quantification shape a process of epistemological border-crossing of both bio-knowledge and biological material, enabling laboratory evidence to be translated into clinically actionable knowledge (Wainwright et al, 2006). This process can be expressed as clinical technomimicry: the set of sociomaterial practices distributed in the laboratory which shape the epistemological congruence between scientific research and clinical action (Lewis et al, 2014).…”

Section: Resultsmentioning

confidence: 99%

“…Recent literature on translational research has addressed the issue of epistemic coordination between laboratory and clinic by framing translational biomedicine as promissory science, emphasising the performativity of technoscientific expectations in mediating laboratory and clinical practices (Wainwright et al, 2006;Martin et al, 2008;Brosnan and Michael, 2014;Crabu, 2014a).…”

Section: Theoretical Considerationsmentioning

confidence: 99%

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Translational biomedicine in action: Constructing biomarkers across laboratory and benchside

Crabu

2016

Soc Theory Health

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This article, based on ethnographic research conducted in a major Italian institution specialising in cancer care and research, provides insight into the clinical and basic research laboratory practices articulated around an experimental protocol designed to develop a biomarker. The article adopts an 'ecological' perspective matured in the field of science and technology studies of the translational process and suggests that biomedical activities are multi-directional, and cannot be understood in reductionist terms, that is, as a two-way linear transfer of bio-knowledge from the bench to bedside and back. I propose the notion of technomimicry, in its dual acceptation in the clinical and experimental sense, to understand the cognitive, social and material strategies involved in the circuit of migration of heterogeneous materials and information across scientific laboratories and clinics. Clinical and experimental technomimicry theoretically capture the multi-directional and multi-modal process of the re-location of materials and bio-knowledge from one site to another. These concepts also highlight how the epistemological boundaries of the clinic and laboratory are required to be mutually adjusted and continuously realigned in order to translate laboratory facts into clinical activities, and clinical evidence into researchable issues.

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Section: Resultsmentioning

confidence: 99%

Section: Theoretical Considerationsmentioning

confidence: 99%

Translational biomedicine in action: Constructing biomarkers across laboratory and benchside

Crabu

2016

Soc Theory Health

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“…The power of these expectations to attract investment depends largely on their perceived feasibility, and scientists, who assert the legitimacy and attractiveness of their research, tend to be proactive agents in making future projections (Morrison 2012;Wainwright et al 2006b). Also, corporate actors may reproduce such projections to substantiate their business models, sometimes altering research trajectories in the field (Martin et al 2008;Petersen and Seear 2011;Wainwright et al 2006a).…”

Section: Sociotechnical Imaginaries and Their Lock-in Effectmentioning

confidence: 99%

State-Supported Science and Imaginary Lock-in: The Case of Regenerative Medicine in Japan

Mikami

2014

Science as Culture

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“…cardiac tissue repair; use of somatic cell nuclear transfer to create embryonic stem cells; creation of induced pluripotent stem cells from human skin cells and direct reprogramming of adult cells), the ethical and social debate has somewhat overshadowed the many other important issues that affect the stem cell field globally. These include: diverging and inconsistent national regulations and standards for the retrieval, storage, supply, trade and use of stem cells (Caulfield 2009 et al;Wainwright et al, 2006); financing (Moran, 2007); and intellectual property issues (Spalding and Simkin 2007).…”

Section: Biomedical and Health Innovation Through Stem Cell-derived Tmentioning

confidence: 99%

Toward New Models for Innovative Governance of Biomedicine and Health Technologies

2013

OECD Science, Technology and Industry Policy Papers

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The OECD Directorate for Science, Technology and Industry (www.oecd.org/sti) develops evidence-based policy advice on the contribution of science, technology and industry to wellbeing and economic growth. STI Policy Papers cover a broad range of topics, including industry and globalisation, innovation and entrepreneurship, scientific R&D and emerging technologies. These reports are officially declassified by an OECD Committee. Note to Delegations: This document is also available on OLIS under reference code: DSTI/STP/BIO(2013)8/FINAL

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From bench to bedside? Biomedical scientists’ expectations of stem cell science as a future therapy for diabetes

Cited by 96 publications

References 25 publications

Translational biomedicine in action: Constructing biomarkers across laboratory and benchside

Translational biomedicine in action: Constructing biomarkers across laboratory and benchside

State-Supported Science and Imaginary Lock-in: The Case of Regenerative Medicine in Japan

Toward New Models for Innovative Governance of Biomedicine and Health Technologies

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