Objective: Although informant report of examinee functioning has previously been associated with examinee-generated performance and cognitive symptom invalidity performance and symptoms validity test (PVT; SVT-C), extant data are limited, and empirically derived guidelines for interpreting informant-report validity are lacking. This study sought to (a) replicate the association of a widely used informant-report measure, the Dementia Severity Rating Scale (DSRS), and examinee-generated PVT/SVT-C in a larger/enriched sample and (b) recommend clinical cutoffs for informant-report invalidity. Method: Data were collected from 145 examinee–informant dyads who completed neuropsychological batteries as part of a routine workup in an epilepsy monitoring unit (EMU). PVT status was determined using two approaches based on combinations of three indicators, whereas SVT-C status was determined using three approaches based on combinations of two indicators. Receiver operating characteristic curves assessed the classification accuracy of the DSRS for discriminating PVT/SVT-C status. Results: The DSRS demonstrated acceptable accuracy in classifying PVT and SVT-C status across operationalizations (PVT AUCs = .71–.77; SVT-C AUCs = .71–.74). Replication sample data indicated the DSRS accurately classified PVT status area under the curves (AUCs = .73–.80), with a large-to-very large effect size across operationalizations (d = −.99 to −1.51). Replication sample data indicated the DSRS was inconsistent in accurately classifying SVT-C (AUCs = .63–.72), though a medium-to-large effect size was observed across operationalizations (d = −.71 to −.98). Conclusion: We replicate previously published associations of informant-reported examinee functioning and examinee-generated PVT/SVT-C. The results suggest empirically derived psychometric guidelines for interpreting informant reports as noncredible on an EMU and lay groundwork for future investigations of informant-report response validity.