From Bedside to Bench? Communities of Promise, Translational Research and the Making of Blood Stem Cells

Martin, Paul; Brown, Nik; Kraft, Alison

doi:10.1080/09505430701872921

Cited by 111 publications

(98 citation statements)

References 20 publications

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“…The power of these expectations to attract investment depends largely on their perceived feasibility, and scientists, who assert the legitimacy and attractiveness of their research, tend to be proactive agents in making future projections (Morrison 2012;Wainwright et al 2006b). Also, corporate actors may reproduce such projections to substantiate their business models, sometimes altering research trajectories in the field (Martin et al 2008;Petersen and Seear 2011;Wainwright et al 2006a). In this future-oriented enterprise, however, nation states tend to be portrayed as more reactive agents, being enrolled in the emerging network of a projected future and providing public funds for its realization.…”

Section: Sociotechnical Imaginaries and Their Lock-in Effectmentioning

confidence: 99%

State-Supported Science and Imaginary Lock-in: The Case of Regenerative Medicine in Japan

Mikami

2014

Science as Culture

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Section: Sociotechnical Imaginaries and Their Lock-in Effectmentioning

confidence: 99%

State-Supported Science and Imaginary Lock-in: The Case of Regenerative Medicine in Japan

Mikami

2014

Science as Culture

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“…Aside from the highly promissory discourses that initially secured the attention of STS scholars (Brown 2003;Martin, Brown, and Kraft 2008;Martin, Brown, and Turner 2008;Brown 2005), low expectations have also been the subject of scholarly examination. While they do not use the term "sociology of expectations" per se, Moreira and Palladino (2005) can be considered to have provided an analytic platform for studying low expectations.…”

Section: Conceptual Backgroundmentioning

confidence: 99%

(Low) Expectations, Legitimization, and the Contingent Uses of Scientific Knowledge: Engagements with Neuroscience in Scottish Social Policy and Services

Broer

Pickersgill

2015

Engaging STS

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Neuroscientific research increasingly sparks the imaginations and hopes of policymakers. Whilst the diversity of assertive statements being made on the basis of neuroscience has been well documented, less frequently explored are more contingent discourses regarding studies of the brain. In this paper, we analyze how social policy and service actors discuss their engagements with neuroscientific terms, concepts and findings. These are mobilized, for one, to substantiate and enlarge the focus of existing policy-for example to attract funding for different target groups (such as babies, people who just retired, etc.)-as well as to help develop (new) policies and services. We show how, in so doing, invocation of the neurosciences can act to align "mutual imagined understandings" among policy actors, practitioners and parents. Tentativeness and ambivalence also figured within our respondents' accounts of the use of the neurosciences. They argued that research had to be simplified in order to make it relevant for wider stakeholders (including politicians), whilst simultaneously considering simplification problematic in some cases. Our analysis foregrounds the different complexities, ambivalences, reductions and instrumentalizations involved in policy and service engagements with the neurosciences, rendering challengeable any notion that (ideas about) neuroscientific research "determines" policy in a linear sense.

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“…Recent literature on translational research has addressed the issue of epistemic coordination between laboratory and clinic by framing translational biomedicine as promissory science, emphasising the performativity of technoscientific expectations in mediating laboratory and clinical practices (Wainwright et al, 2006;Martin et al, 2008;Brosnan and Michael, 2014;Crabu, 2014a).…”

Section: Theoretical Considerationsmentioning

confidence: 99%

Translational biomedicine in action: Constructing biomarkers across laboratory and benchside

Crabu

2016

Soc Theory Health

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This article, based on ethnographic research conducted in a major Italian institution specialising in cancer care and research, provides insight into the clinical and basic research laboratory practices articulated around an experimental protocol designed to develop a biomarker. The article adopts an 'ecological' perspective matured in the field of science and technology studies of the translational process and suggests that biomedical activities are multi-directional, and cannot be understood in reductionist terms, that is, as a two-way linear transfer of bio-knowledge from the bench to bedside and back. I propose the notion of technomimicry, in its dual acceptation in the clinical and experimental sense, to understand the cognitive, social and material strategies involved in the circuit of migration of heterogeneous materials and information across scientific laboratories and clinics. Clinical and experimental technomimicry theoretically capture the multi-directional and multi-modal process of the re-location of materials and bio-knowledge from one site to another. These concepts also highlight how the epistemological boundaries of the clinic and laboratory are required to be mutually adjusted and continuously realigned in order to translate laboratory facts into clinical activities, and clinical evidence into researchable issues.

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From Bedside to Bench? Communities of Promise, Translational Research and the Making of Blood Stem Cells

Cited by 111 publications

References 20 publications

State-Supported Science and Imaginary Lock-in: The Case of Regenerative Medicine in Japan

State-Supported Science and Imaginary Lock-in: The Case of Regenerative Medicine in Japan

(Low) Expectations, Legitimization, and the Contingent Uses of Scientific Knowledge: Engagements with Neuroscience in Scottish Social Policy and Services

Translational biomedicine in action: Constructing biomarkers across laboratory and benchside

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