From Assessment to Implementation and Beyond in Cancer and Aging Research

Lichtman, Stuart M.; Cohen, Harvey Jay; Muss, Hyman B.; Tew, William P.; Korc‐Grodzicki, Beatriz

doi:10.1200/jco.21.00317

Cited by 8 publications

(6 citation statements)

References 96 publications

(121 reference statements)

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“…Common provider barriers, such as misperceptions of the value of geriatric assessment and lack of time are important factors to consider. However, understanding the care delivery system‐related factors that contribute to these common barriers is critical as well 21,22 . Healthcare delivery‐related factors may include organizational readiness/capacity, teamwork processes, and options in relation to care delivery approaches (i.e., in‐person/telehealth).…”

Section: Discussionmentioning

confidence: 99%

“…However, understanding the care delivery systemrelated factors that contribute to these common barriers is critical as well. 21,22 Healthcare delivery-related factors may include organizational readiness/capacity, teamwork processes, and options in relation to care delivery approaches (i.e., in-person/telehealth). Importantly, research that addresses the patient/family, oncologist/clinician, and healthcare system levels while simultaneously integrating a health equity lens are critical to achieving successful integration of geriatric assessment as part of standard care.…”

Section: Discussionmentioning

confidence: 99%

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Healthcare delivery research in older adults with cancer: A review of National Institutes of Health‐funded projects

Sun

Tuovinen

Jacobsen

et al. 2023

J American Geriatrics Society

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Background Cancer is a disease of aging, and most people with cancer are older than 65. However, widespread uptake of evidence‐based approaches that facilitate quality care delivery for older adults with cancer are lacking. This project aimed to review National Institutes of Health (NIH) grants funded in the last decade that focused on healthcare delivery in aging and older adults with cancer, and to examine grant‐related characteristics, study designs, and scientific topics included. Methods A search was conducted of all extramural NIH research grants awarded between fiscal year 2012 to 2021. We examined NIH terms; keyword searches of titles, abstracts, and specific aims were implemented to maximize search efficiency. Extraction criteria focused on grant‐related and study characteristics. A priori scientific topics for coding included geriatric assessment, care decision‐making, communication, care coordination, physical and psychosocial functioning/symptoms, and clinical outcomes. Results A total of 48 funded grants met the inclusion criteria. A near‐equal split was observed between R03, R21, and R01 grants. Most grants did not include family caregivers or focus on end‐of‐life care. Most grants included multiple cancers and were conducted during active treatment and in hospital/clinic settings. Common scientific topics included geriatric assessment, care decision‐making, physical and psychosocial functioning/symptoms, communication, and care coordination. Few grants focused on cognitive functioning. Conclusions Several gaps in the portfolio were identified, including family caregiver inclusion, end‐of‐life care, and studies focusing on cognitive functioning.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Healthcare delivery research in older adults with cancer: A review of National Institutes of Health‐funded projects

Sun

Tuovinen

Jacobsen

et al. 2023

J American Geriatrics Society

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“…Baseline geriatric function assessment before surgery was performed using TMIG-IADL 20 , 21 (see Supplementary Table 1 A for specific questionnaires and scores) and G8 22 (see Supplementary Table 1 B for specific questionnaires and scores). Baseline information on the social situation, such as habitation, CCI score 23 (see Supplementary Table 1 C for specific conditions and scores), polypharmacy status, 24 and Japanese version EQ-5D-5L scores 18 , 19 , 25 (see Supplementary Table 1 D for specific questionnaires), were also obtained before surgery. Surgical procedures were not specified in the study protocol.…”

Section: Methodsmentioning

confidence: 99%

Prospective, Multi-Institutional Observational Study of Deterioration in Activities of Daily Living in Elderly Patients After Lung Cancer Surgery

Takei¹,

Kunitoh²,

Wakabayashi³

et al. 2023

JTO Clinical and Research Reports

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“…The mechanistic roles of DNMT3A and TET2 in malignant hematopoiesis have been extensively summarized elsewhere [102,103]. The impact of CH on health-related outcomes is most notable in non-hematological diseases closely associated with aging, such as cardiovascular disease (CVD) and solid tumors [87,96,100,[104][105][106][107][108][109]. Among these, atherosclerosis is the most extensively studied CVD linked to CH [96,[110][111][112][113][114][115][116].…”

Section: Epigenetics In Acquisition Of Clonal Hematopoiesis With Agementioning

confidence: 99%

Epigenetic Mechanisms in Hematologic Aging and Premalignant Conditions

Yan,

Yuan,

Guryanova

2023

Epigenomes

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Hematopoietic stem cells (HSCs) are essential for maintaining overall health by continuously generating blood cells throughout an individual’s lifespan. However, as individuals age, the hematopoietic system undergoes significant functional decline, rendering them more susceptible to age-related diseases. Growing research evidence has highlighted the critical role of epigenetic regulation in this age-associated decline. This review aims to provide an overview of the diverse epigenetic mechanisms involved in the regulation of normal HSCs during the aging process and their implications in aging-related diseases. Understanding the intricate interplay of epigenetic mechanisms that contribute to aging-related changes in the hematopoietic system holds great potential for the development of innovative strategies to delay the aging process. In fact, interventions targeting epigenetic modifications have shown promising outcomes in alleviating aging-related phenotypes and extending lifespan in various animal models. Small molecule-based therapies and reprogramming strategies enabling epigenetic rejuvenation have emerged as effective approaches for ameliorating or even reversing aging-related conditions. By acquiring a deeper understanding of these epigenetic mechanisms, it is anticipated that interventions can be devised to prevent or mitigate the rates of hematologic aging and associated diseases later in life. Ultimately, these advancements have the potential to improve overall health and enhance the quality of life in aging individuals.

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From Assessment to Implementation and Beyond in Cancer and Aging Research

Abstract: Author affiliations and support information (if applicable) appear at the end of this article.

Cited by 8 publications

References 96 publications

Healthcare delivery research in older adults with cancer: A review of National Institutes of Health‐funded projects

Healthcare delivery research in older adults with cancer: A review of National Institutes of Health‐funded projects

Prospective, Multi-Institutional Observational Study of Deterioration in Activities of Daily Living in Elderly Patients After Lung Cancer Surgery

Epigenetic Mechanisms in Hematologic Aging and Premalignant Conditions

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