From ASCA breakthrough in Crohn's disease and Candida albicans research to thirty years of investigations about their meaning in human health

Sendid, Boualem; Cornu, Marjorie; Cordier, Camille; Bouckaert, Julie; Colombel, Jean Frederic; Poulain, Daniel

doi:10.1016/j.autrev.2023.103486

Cited by 5 publications

References 238 publications

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Veränderte T-Zell-Reaktion gegen Hefepilze bei chronischer Darmentzündung

Martini,

Bacher

2024

Biospektrum

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Inappropriate CD4+ T cell responses against species of the intestinal microbiome have been suggested to contribute to the chronic inflammation of Crohn’s disease (CD). However, the microbial species that drive such inappropriate CD4+ T cell responses and the pathogenic T cell functions in CD remain largely unknown. Our work provides evidence that aberrant cytotoxic Th 1 cells directed against both commensal and food-derived yeasts may contribute to the inflammatory immune response in patients with CD.

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Veränderte T-Zell-Reaktion gegen Hefepilze bei chronischer Darmentzündung

Martini,

Bacher

2024

Biospektrum

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Avancées dans le diagnostic biologique des maladies inflammatoires chroniques de l’intestin

Carlé,

Bost,

Cosquer

et al. 2024

Revue Francophone des Laboratoires

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Candida and Long Covid

Chambers

2024

Preprint

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The pandemic has supercharged growing awareness of the gut microbiome as a critical determinant of human health. Long haulers share microbiomes similar to those seen in myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia, all frequently associated with Candida overgrowth (CO). Candida has a unique relationship with IDO and ATM, mediated by IFN-γ. Zonulin, a circulating protein that increases intestinal and endothelial permeability, has emerged as a central player. This protein can be activated by proteases secreted by Candida, opening the door to myriad autoimmune and other chronic diseases. Many of these are seen in long Covid (LC). Candida hyphal walls express proteins that are analogous to gliadin/gluten (celiac disease antibodies) or that are GPCRs, e.g., Crohn’s disease antibodies present only in eukaryotes that may trigger antigliadin and anti-GPCR autoantibodies respectively. These two autoantibody producing pathways both activate zonulin and may encompass the broad spectrum of autoimmune diseases seen in LC. IFN-γ, a marker for LC, can activate not only IDO but also zonulin. The spike protein S on SARS CoV2 can attach to both the ACE2 receptor (required for tryptophan absorption) and Toll-like receptor4 (TLR4) bearing cells (endothelial cells and enterocytes). The latter can also activate zonulin. A hypothetical pathophysiologic model is proposed implicating pre-existing CO, aggravated by Covid-19, in not only the genesis of LC but also that of autoimmune disease, dementia, cancer, many chronic diseases, and aging. Candida may accomplish this directly or through IFN-γ induced upregulation of both IDO and zonulin.

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From ASCA breakthrough in Crohn's disease and Candida albicans research to thirty years of investigations about their meaning in human health

Cited by 5 publications

References 238 publications

Veränderte T-Zell-Reaktion gegen Hefepilze bei chronischer Darmentzündung

Veränderte T-Zell-Reaktion gegen Hefepilze bei chronischer Darmentzündung

Avancées dans le diagnostic biologique des maladies inflammatoires chroniques de l’intestin

Candida and Long Covid

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