From aneurysmal bone cyst to telangiectatic osteosarcoma with metastasis in inguinal lymph nodes: Case report

Janevska, Vesna; Spasevska, Liljana; Samardziski, Milan; Nikodinovska, Violeta Vasilevska; Zhivadinovik, Julija; Trajkovska, Elizabeta

doi:10.2298/mpns1504127j

Cited by 8 publications

(5 citation statements)

References 11 publications

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“…Malignant transformation is unlikely, but a few cases have been reported in people and there is one case report in a dog. [4][5][6][7] The clinical signs of pain, swelling and functional impairment are frequently reported. Few ABCs are discovered as an incidental finding.…”

Section: Introductionmentioning

confidence: 99%

Aneurysmal bone cyst in the pelvis of a cat: successful outcome of partial iliectomy with limb preservation

Winbladh¹,

Fransson

Svensson³

et al. 2020

Journal of Feline Medicine and Surgery Open Reports

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Case summary A 3-year-old spayed female domestic shorthair indoor cat presented with a 3-week history of pain from the pelvic region. Physical examination revealed pain elicited on palpating the pelvic area and right hip. Radiographs and CT showed an expansile, osteolytic process with intact cortex in the right wing of the ilium. CT revealed a monostotic and soft tissue-attenuating process with clear margins. Preoperative histopathological diagnosis of aneurysmal bone cyst was made from incisional biopsies. The cyst was removed en bloc with limb-sparing partial iliectomy. Histopathology confirmed the diagnosis of aneurysmal bone cyst. Recovery from surgery was uneventful. At re-examination 8 weeks and 8 months postoperatively, the cat was pain free and physical examinations were within normal limits. Relevance and novel information Feline aneurysmal bone cysts are rare and reported cases are few. To our knowledge, this is the first report describing the CT appearance of a pelvic aneurysmal bone cyst and partial iliectomy with limb preservation in a cat with successful short-term outcome.

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Section: Introductionmentioning

confidence: 99%

Aneurysmal bone cyst in the pelvis of a cat: successful outcome of partial iliectomy with limb preservation

Winbladh¹,

Fransson

Svensson³

et al. 2020

Journal of Feline Medicine and Surgery Open Reports

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“…Bone cysts and osteosarcoma are tumor-like lesions of the bone. Bone cysts are mainly treated with surgery, which is associated with good prognosis; however, osteosarcoma is the most common malignant bone tumor that has poor prognosis, often resulting in metastatic disease ( 1 – 3 ). It represents 15% of all primary bone tumors and 0.2% of all malignant tumors in children and young adults ( 4 – 7 ).…”

Section: Introductionmentioning

confidence: 99%

PYGB siRNA inhibits the cell proliferation of human osteosarcoma cell lines

et al. 2018

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Osteosarcoma is the most common malignant bone carcinoma that primarily occurs between childhood to adolescence. It was suggested by recent research that the Brain type glycogen phosphorylase (PYGB) gene may serve an important role in various types of cancer. In the present study, the PYGB gene was knocked down in order to evaluate the cell viability, invasion and migration of the human osteosarcoma cell lines MG63 and HOS. The expression levels of PYGB in osteosarcoma and bone cyst tissue samples, as well as in the osteosarcoma cell lines were identified using reverse transcription-quantitative polymerase chain reaction and western blot assay. Subsequently, a Cell Counting kit 8 assay was employed to evaluate cell proliferation. Cell apoptosis rate and cell cycle distribution were measured by flow cytometry. In addition, cell invasion and migration were evaluated through a Transwell assay. The expression levels of the cell apoptosis and tumor metastasis associated proteins B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein, E-cadherin, Twist, matrix metalloproteinase (MMP)-9 and MMP2 were measured via western blotting. PYGB exhibited a higher expression level in the osteosarcoma tissue samples, particularly in the human osteosarcoma cell lines MG63 and HOS. Knockdown of PYGB resulted in a decline in cell proliferation, invasion and migration, which was coupled with induced cell apoptosis and cell cycle arrest in MG63 and HOS cells. Furthermore, alterations in the expression of apoptosis and metastasis associated proteins indicated that small interfering (si)PYGB may have regulated cell viability by targeting the Bcl/Caspase and cyclin dependent kinase (CDK)-1 signaling pathway. In conclusion, PYGB siRNA exerted an inhibitory effect on the cell viability of the human osteosarcoma cells MG63 and HOS by blocking the Caspase/Bcl and CDK1 signaling pathway, highlighting novel potential therapeutic methods for treating osteosarcoma.

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“…The malignant factors that emerged during the treatment of this case and a review of the relevant literature are considered as follows. First, there is the possibility of previously combined osteosarcoma, but the absence of osteosarcoma tissue in the first two pathological examinations was due to the osteosarcoma being in an early stage, the imaging presentation being unusual, the tumor being small and contained, or the inability to collect pathological sections ( 21 ). Second, it was considered that the first two pathological examinations were probably telangiectatic osteosarcoma, whose histological morphology was highly similar to ABC.…”

Section: Discussionmentioning

confidence: 99%

Malignant transformation of an aneurysmal bone cyst of the femoral neck: A case report

et al. 2023

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Aneurysmal bone cyst (ABC) is a benign, distending, osteolytic and locally aggressive bone tumor that is mostly associated with trauma. Approximately 1% of bone tumors are ABCs, which are most prevalent in adolescents and are usually detected in the spine and long tubular bones. The diagnosis of ABC mainly relies on histopathology, malignant transformation is rare, and the chance of malignancy increases if there are multiple recurrences. Due to the rarity of reports of malignant transformation of ABCs into osteosarcoma, there is still considerable debate on the appropriate treatment strategy. The current paper presents a case of aneurysmal bone cyst malignant to osteosarcoma and the therapeutic measures to provide expertise for the diagnosis and treatment of ABCs that are malignant to osteosarcoma.

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From aneurysmal bone cyst to telangiectatic osteosarcoma with metastasis in inguinal lymph nodes: Case report

Abstract: We emphasize the importance of team work in order to achieve the accurate diagnosis, highlighting careful radiological examinations, good sampling and awareness of unusual cases in bone tumor pathology.

Cited by 8 publications

References 11 publications

Aneurysmal bone cyst in the pelvis of a cat: successful outcome of partial iliectomy with limb preservation

Aneurysmal bone cyst in the pelvis of a cat: successful outcome of partial iliectomy with limb preservation

PYGB siRNA inhibits the cell proliferation of human osteosarcoma cell lines

Malignant transformation of an aneurysmal bone cyst of the femoral neck: A case report

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