From adults to pediatrics: A review noninvasive brain stimulation (NIBS) to facilitate recovery from brain injury

O’Leary, Georgia H.; Jenkins, Dorothea; Coker-Bolt, Patricia; George, Mark S.; Kautz, Steven A.; Bikson, Marom; Gillick, Bernadette T.; Badran, Bashar W.

doi:10.1016/bs.pbr.2021.01.019

Cited by 9 publications

(5 citation statements)

References 152 publications

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“…Non-invasive brain stimulation (NIBS), including repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), may facilitate patient recovery by modulating cortical excitability and increasing dendritic spines and their connections [ 5 , 6 , 7 ]. These techniques have potential for treating multiple neuropsychiatric disorders, including depression [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Non-Invasive Brain Stimulation for Treating Depression in Patients with Traumatic Brain Injury: A Meta-Analysis and Meta-Regression of Randomized Controlled Trials

Chang,

Chou,

Chuang

et al. 2023

JCM

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Objective: This meta-analysis aimed to ascertain the efficacy of non-invasive brain stimulation (NIBS)—comprising repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS)—for depression in traumatic brain injury (TBI) patients. Methods: Comprehensive searches were conducted in PubMed, Cochrane Database of Systematic Reviews, and the Cochrane Central Register of Controlled Trials up to 28 January 2023. Random-effects models assessed the treatment effects, and heterogeneity was evaluated through I2 statistics and funnel plot inspection. Results: From 10 trials (234 participants; 8 rTMS, 2 tDCS), NIBS was found significantly more effective than sham in alleviating depressive symptoms (SMD: 0.588, 95% CI: 0.264–0.912; p < 0.001). rTMS, specifically, showed higher efficacy (SMD: 0.707, 95% CI: 0.306–1.108; p = 0.001) compared to sham, whereas tDCS outcomes were inconclusive (SMD: 0.271, 95% CI: −0.230 to 0.771; p = 0.289). Meta-regression found no correlation with the number of sessions, treatment intensity, or total dose. Notably, while post-treatment effects were significant, they diminished 1–2 months post intervention. Adverse events associated with NIBS were minimal, with no severe outcomes like seizures and suicide reported. Conclusions: rTMS emerged as a potent short-term intervention for depression in TBI patients, while tDCS findings remained equivocal. The long-term efficacy of NIBS is yet to be established, warranting further studies. The low adverse event rate reaffirms NIBS’s potential safety.

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Section: Introductionmentioning

confidence: 99%

Efficacy of Non-Invasive Brain Stimulation for Treating Depression in Patients with Traumatic Brain Injury: A Meta-Analysis and Meta-Regression of Randomized Controlled Trials

Chang,

Chou,

Chuang

et al. 2023

JCM

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“…There is strong evidence in animal and adult rehabilitation literature that vagus nerve stimulation paired with active rehabilitation treatment promotes beneficial neuroplasticity leading to improved motor outcomes ( 36 , 37 ). Our data and others suggest that taVNS may have similar benefits and is safe in vulnerable infant populations ( 12 , 21 , 31 , 38 – 38 ).…”

Section: Discussionmentioning

confidence: 99%

Pairing taVNS and CIMT is feasible and may improve upper extremity function in infants

McGloon,

Humanitzki,

Brennan

et al. 2024

Front. Pediatr.

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In this study we combined non-invasive transcutaneous auricular vagal nerve stimulation (taVNS) with 40 h of constraint induced movement therapy (CIMT) in infants. All infants completed the full intervention with no adverse events. Therapists were able to maintain high treatment fidelity and reported high ratings for ease of use and child tolerance. Preliminary results show promising gains on motor outcomes: Mean QUEST increase 19.17 (minimal clinically important difference, MCID 4.89); Mean GMFM increase 13.33 (MCID 1%–3%). Infants also exceeded expectations on Goal Attainment Scores (+1). Early data is promising that taVNS paired with intensive motor CIMT is feasible, reliable, and safe in young infants with hemiplegia, and may help harness activity-dependent plasticity to enhance functional movement.

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“…These results could be clinically important in neuro-rehabilitation. For example, neuromodulation therapies, such as repetitive transcranial magnetic stimulation and transcranial direct current stimulation, could be applied to the contra-lesional CRT for motor recovery of the paretic leg when a patient shows complete injuries to the ipsilesional corticospinal tract and CRT (O'Brien et al, 2018;O'Leary et al, 2021). On the other hand, only three studies were reviewed, and one was a case report.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies suggested that the CRST is important in the motor function, next to the corticospinal tract, in the human brain (Nathan and Smith, 1955;Do et al, 2013;Jang, 2014;Lee and Jang, 2015;Jang and Lee, 2019). Therefore, detailed knowledge of the CRST is clinically important, particularly neuro-rehabilitation (Li, 2017;O'Brien et al, 2018,O'Leary et al, 2021.…”

Section: Introductionmentioning

confidence: 99%

Role of the Contra-Lesional Corticoreticular Tract in Motor Recovery of the Paretic Leg in Stroke: A Mini-Narrative Review

Jang

Cho

2022

Front. Hum. Neurosci.

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This review discusses the role of the contra-lesional corticoreticular tract (CRT) in motor recovery of the paretic leg in stroke patients by reviewing related diffusion tensor tractography studies. These studies suggest that the contra-lesional CRT can contribute to the motor recovery of the paretic leg in stroke patients, particularly in patients with complete injuries of the ipsilesional corticospinal tract and CRT. Furthermore, a review study reported that the motor recovery of the paretic ankle dorsiflexor, which is mandatory for achieving a good gait pattern without braces in hemiparetic stroke patients, was closely related to the contra-lesional CRT. These results could be clinically important in neuro-rehabilitation. For example, the contra-lesional CRT could be a target for neuromodulation therapies in patients with complete injuries of the ipsilesional corticospinal tract and CRT. On the other hand, only three studies were reviewed in this review and one was a case report. Although the CRT has been suggested to be one of the ipsilateral motor pathways from the contra-lesional cerebral cortex to the paretic limbs in stroke, the role of the CRT has not been elucidated clearly. Therefore, further prospective follow-up studies combining functional neuroimaging and transcranial magnetic stimulation for the paretic leg with diffusion tensor tractography will be useful for elucidating the role of the contra-lesional CRT in stroke patients.

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From adults to pediatrics: A review noninvasive brain stimulation (NIBS) to facilitate recovery from brain injury

Cited by 9 publications

References 152 publications

Efficacy of Non-Invasive Brain Stimulation for Treating Depression in Patients with Traumatic Brain Injury: A Meta-Analysis and Meta-Regression of Randomized Controlled Trials

Efficacy of Non-Invasive Brain Stimulation for Treating Depression in Patients with Traumatic Brain Injury: A Meta-Analysis and Meta-Regression of Randomized Controlled Trials

Pairing taVNS and CIMT is feasible and may improve upper extremity function in infants

Role of the Contra-Lesional Corticoreticular Tract in Motor Recovery of the Paretic Leg in Stroke: A Mini-Narrative Review

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