From Abuse to Violence: Psychophysiological Consequences of Maltreatment

Lewis, Dorothy Otnow

doi:10.1097/00004583-199205000-00001

Cited by 174 publications

(69 citation statements)

References 74 publications

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“…Some PTSD researchers have developed models that specify neurological changes following traumatic experiences (Lewis, 1992;Southwick et al, 1997;Stein, Hanna, Koverola, Torchia, & McLarty, 1997;Yehuda, 1998), but to date, no clear picture of the biological response to trauma has emerged from research.…”

Section: Biological Factorsmentioning

confidence: 99%

A Conceptual Framework for the Impact of Traumatic Experiences

Carlson

Dalenberg

2000

Trauma, Violence, & Abuse

155

129

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Section: Biological Factorsmentioning

confidence: 99%

A Conceptual Framework for the Impact of Traumatic Experiences

Carlson

Dalenberg

2000

Trauma, Violence, & Abuse

155

129

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“…Indeed, it has been shown that aggressive behavior can be associated with stressors including early life trauma and childhood maltreatment [Widom, 1989;Lewis, 1992;Loeber and Stouthamer-Loeber, 1998;Hildyard and Wolfe, 2002;Ethier et al, 2004;Fonagy, 2004;Veenema et al, 2006]. Furthermore, these behavioral processes are also associated with numerous psychopathologies including major depressive disorder, schizophrenia, personality disorders, anxiety disorders, and post-traumatic stress disorder [Agid et al, 1999;Veenema, 2009].…”

Section: Introductionmentioning

confidence: 99%

Comparative mRNA analysis of behavioral and genetic mouse models of aggression

Malki

Tosto

Pain

et al. 2016

American J of Med Genetics Pt B

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Mouse models of aggression have traditionally compared strains, most notably BALB/cJ and C57BL/6. However, these strains were not designed to study aggression despite differences in aggression-related traits and distinct reactivity to stress. This study evaluated expression of genes differentially regulated in a stress (behavioral) mouse model of aggression with those from a recent genetic mouse model aggression. The study used a discovery-replication design using two independent mRNA studies from mouse brain tissue. The discovery study identified strain (BALB/cJ and C57BL/6J) × stress (chronic mild stress or control) interactions. Probe sets differentially regulated in the discovery set were intersected with those uncovered in the replication study, which evaluated differences between high and low aggressive animals from three strains specifically bred to study aggression. Network analysis was conducted on overlapping genes uncovered across both studies. A significant overlap was found with the genetic mouse study sharing 1,916 probe sets with the stress model. Fifty-one probe sets were found to be strongly dysregulated across both studies mapping to 50 known genes. Network analysis revealed two plausible pathways including one centered on the UBC gene hub which encodes ubiquitin, a protein well-known for protein degradation, and another on P38 MAPK. Findings from this study support the stress model of aggression, which showed remarkable molecular overlap with a genetic model. The study uncovered a set of candidate genes including the Erg2 gene, which has previously been implicated in different psychopathologies. The gene networks uncovered points at a Redox pathway as potentially being implicated in aggressive related behaviors.

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“…I t is being increasingly recognized that the interaction between environmental and biological factors may be particularly important in the development of crime and violence (1)(2)(3). Empirical support for such a view is nevertheless surprisingly limited.…”

mentioning

confidence: 99%

Interaction between birth complications and early maternal rejection in predisposing individuals to adult violence: specificity to serious, early-onset violence

Raine

Brennan²,

Mednick³

1997

AJP

158

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I t is being increasingly recognized that the interaction between environmental and biological factors may be particularly important in the development of crime and violence (1-3). Empirical support for such a view is nevertheless surprisingly limited. In a previous study conducted with Danish subjects (4), we found support for the biosocial perspective. That study tested the biosocial interaction hypothesis that birth complications, when combined with early maternal rejection of the infant, predispose to adult violent crime. A highly significant interaction between birth complications and early maternal rejection indicated that individuals who suffered both birth complications and early childhood rejection were most likely to become violent offenders in adulthood. The effect was specific to violence and was not observed for nonviolent criminal offending.That study had a number of limitations. First, although the sample was initially large, the low base rate of criminal violence in Denmark meant that cell sizes in the four groups based on violence outcome were relatively small. Second, the relatively small group sizes for violence outcome meant that we were not able to examine which types of violent criminal offending the biosocial interaction specifically applied to. There appears to be little research on the differential correlates of threats of violence versus serious physical violence. One important question, therefore, is whether the biosocial interaction applies to all forms of violence including threats or whether it is more specific to serious physical violence.Third, because subjects' violent offending was assessed at age 18 years, we were not able to analyze whether the interaction effect was specific to early-onset violent offenders or whether it generalizes to offenders who commit violence in adulthood after age 18. Surprisingly little is known about differences between

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From Abuse to Violence: Psychophysiological Consequences of Maltreatment

Cited by 174 publications

References 74 publications

A Conceptual Framework for the Impact of Traumatic Experiences

A Conceptual Framework for the Impact of Traumatic Experiences

Comparative mRNA analysis of behavioral and genetic mouse models of aggression

Interaction between birth complications and early maternal rejection in predisposing individuals to adult violence: specificity to serious, early-onset violence

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