From A&amp;E to ICU: how nurses can support the Surviving Sepsis Campaign

Robson, Wayne

doi:10.1016/j.iccn.2004.04.002

Cited by 2 publications

(1 citation statement)

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“…Multiple clinical staff models may be required to achieve a consistent level of quality care for the treatment of sepsis. [242526] This team model plays a vital part in achieving sepsis bundle compliance which resulted in early therapeutic interventions. [22] Logistic issues regarding early hemodynamic optimization limit its generalizability because of inadequate resources even in industrialized country.…”

Section: Discussionmentioning

confidence: 99%

Clinical outcomes after utilizing surviving sepsis campaign in children with septic shock and prognostic value of initial plasma NT-proBNP

Samransamruajkit¹,

Uppala²,

Pongsanon³

et al. 2014

Indian Journal of Critical Care Medicine

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Background and Objective:The surviving sepsis campaign treatment guideline (SSC) implementation is associated with improved outcome in adults with severe sepsis. The effect on outcome of pediatric sepsis is less clear.Purpose:To determine the clinical outcomes of SSC implementation and to investigate the prognostic value of initial plasma NT-proBNP and procalcitonin in children.Materials and Methods:Infants and children (aged 1month/0-15 years with severe sepsis or septic shock) were prospectively enrolled and treated according to the guidelines. Initial blood drawn was saved for NT-pro-BNP, procalcitonin measurements and clinical data were also recorded.Results:A total of 47 subjects were recruited. Since the application of the SSC, our mortality rate had significantly decreased from 42-19% (P = 0.003) as compared to the data in the previous 3 years. Clinical factors that significantly increased the mortality rate were: Initial central venous oxygen saturation < 7 0% after fluid resuscitation [odds ratio (OR) = 23.3; 95% confidence interval (CI) 3.7-143; P = 0.001], and initial albumin level (≤ 3 g/dl, OR = 6.7; 95% CI 1.2-37.5, P = 0.03). There was asignificant difference between the initial NT-proBNP levels between survivors and non survivors, (6280.3 ± 9597 ng/L, P < 0.001), but not for procalcitonin (12.7 ± 24.8, 29.3 ± 46 μg/L, P = 0.1), respectively. An initial NT-proBNP level of more than 11,200 pg/ml predicted Pediatric Intensive Care Unit (PICU) mortality with a sensitivity of 85.7% and a specificity of 90%.Conclusions:A modified SSC for severe sepsis and septic shock significantly reduced the mortality rate in our PICU. High initial NT-ProBNP level was associated with mortality.

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Section: Discussionmentioning

confidence: 99%