From 3D printing to 3D bioprinting: the material properties of polymeric material and its derived bioink for achieving tissue specific architectures

Vrana, Nihal Engin; Gupta, Shubhra; Mitra, Kunal; Rizvanov, Albert A.; Solovyeva, Valeriya V.; Antmen, Ezgi; Salehi, Majid; Ehterami, Arian; Pourchet, Léa; Barthès, Julien; Marquette, Christophe A.; Unge, Magnus von; Wang, Chi-Yun; Lai, Po‐Liang; Bit, Arindam

doi:10.1007/s10561-021-09975-z

Cited by 17 publications

(8 citation statements)

References 131 publications

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“…26,27 Currently, bioink materials used to load complex types of cells in organoid modelling are still very limited in variety and performance. 28 Many existing 3D liver models rely on acellular matrices (e.g., Matrigel) as ECM-mimics that support cells for physical attachment, allow organoids to self-organize and differentiate within them, and provide factors and hormones that influence gene and protein expression. 29,30 However, animal-derived hydrogels have drawbacks, including batch-to-batch variability and species differences, which severely limit their further use in vivo.…”

Section: Discussionmentioning

confidence: 99%

In vitro construction of liver organoids with biomimetic lobule structure by a multicellular 3D bioprinting strategy

Jian

Dong

et al. 2023

Cell Proliferation

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Liver disease is one of the serious threats to human life and health. Three‐dimensional (3D) liver models, which simulate the structure and function of natural liver tissue in vitro, have become a common demand in medical, scientific and pharmaceutical fields nowadays. However, the complex cellular composition and multi‐scale spatial arrangement of liver tissue make it extremely challenging to construct liver models in vitro. According to HepaRG preference and printing strategy, the formulation of bioink system with opposite charge is optimized. The sodium alginate‐based bioink 1 and dipeptide‐based bioink 2 are used to ensure structural integrity and provide flexible designability, respectively. The HepaRG/HUVECs/LX‐2‐laden liver organoids with biomimetic lobule structure are fabricated by a multicellular 3D droplet‐based bioprinting strategy, to mimic the cell heterogeneity, spatial structure and extracellular matrix (ECM) features. The liver organoids can maintain structural integrity and multicellular distribution within the printed lobule‐like structure after 7 days of culture. Compared with the 2D monolayer culture, the constructed 3D organoids show high cell viability, ALB secretion and urea synthesis levels. This study provides a droplet‐based and layer‐by‐layer 3D bioprinting strategy for in vitro construction of liver organoids with biomimetic lobule structure, giving meaningful insights in the fields of new drugs, disease modelling, and tissue regeneration.

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Section: Discussionmentioning

confidence: 99%

In vitro construction of liver organoids with biomimetic lobule structure by a multicellular 3D bioprinting strategy

Jian

Dong

et al. 2023

Cell Proliferation

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“…Then, the obtained STL data is used to print out the tissue or organ. 3) Post-processing: Before transplanting the printed product into the tissue of the patient or test model, it should be placed in a bioreactor to maintain its mechanical properties and biological functionality [ 20 , 21 ].…”

Section: Main Textmentioning

confidence: 99%

Emerging 3D bioprinting applications in plastic surgery

et al. 2023

Biomater Res

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Plastic surgery is a discipline that uses surgical methods or tissue transplantation to repair, reconstruct and beautify the defects and deformities of human tissues and organs. Three-dimensional (3D) bioprinting has gained widespread attention because it enables fine customization of the implants in the patient's surgical area preoperatively while avoiding some of the adverse reactions and complications of traditional surgical approaches. In this paper, we review the recent research advances in the application of 3D bioprinting in plastic surgery. We first introduce the printing process and basic principles of 3D bioprinting technology, revealing the advantages and disadvantages of different bioprinting technologies. Then, we describe the currently available bioprinting materials, and dissect the rationale for special dynamic 3D bioprinting (4D bioprinting) that is achieved by varying the combination strategy of bioprinting materials. Later, we focus on the viable clinical applications and effects of 3D bioprinting in plastic surgery. Finally, we summarize and discuss the challenges and prospects for the application of 3D bioprinting in plastic surgery. We believe that this review can contribute to further development of 3D bioprinting in plastic surgery and provide lessons for related research. Graphical Abstract

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“…By incorporating sensors into the bioprinted constructs, various parameters can be monitored in real-time. 87 For instance, sensors can measure mechanical properties like strain, stress, and stiffness of the regenerating tissue. These measurements provide valuable insights into the structural integrity and functionality of the engineered tissue, enabling clinicians to evaluate the success of the therapy and make necessary adjustments if needed.…”

Section: The Applications Of Bioprinting Dds In Oa Therapymentioning

confidence: 99%

Bioprinting-Enabled Biomaterials: A Cutting-Edge Strategy for Future Osteoarthritis Therapy

Yang,

Liu,

Zhang

et al. 2023

IJN

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Bioprinting is an advanced technology that allows for the precise placement of cells and biomaterials in a controlled manner, making significant contributions in regenerative medicine. Notably, bioprinting-enabled biomaterials have found extensive application as drug delivery systems (DDS) in the treatment of osteoarthritis (OA). Despite the widespread utilization of these biomaterials, there has been limited comprehensive research summarizing the recent advances in this area. Therefore, this review aims to explore the noteworthy developments and challenges associated with utilizing bioprinting-enabled biomaterials as effective DDS for the treatment of OA. To begin, we provide an overview of the complex pathophysiology of OA, highlighting the shortcomings of current treatment modalities. Following this, we conduct a detailed examination of various bioprinting technologies and discuss the wide range of biomaterials employed in DDS applications for OA therapy. Finally, by placing emphasis on their transformative potential, we discuss the incorporation of crucial cellular components such as chondrocytes and mesenchymal stem cells into bioprinted constructs, which play a pivotal role in promoting tissue regeneration and repair.

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From 3D printing to 3D bioprinting: the material properties of polymeric material and its derived bioink for achieving tissue specific architectures

Cited by 17 publications

References 131 publications

In vitro construction of liver organoids with biomimetic lobule structure by a multicellular 3D bioprinting strategy

In vitro construction of liver organoids with biomimetic lobule structure by a multicellular 3D bioprinting strategy

Emerging 3D bioprinting applications in plastic surgery

Bioprinting-Enabled Biomaterials: A Cutting-Edge Strategy for Future Osteoarthritis Therapy

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