From 3D Bioprinters to a fully integrated Organ Biofabrication Line

Passamai, V.E.; Dernowsek, Janaina; Nogueira, Júlia A.; Lara, V.F.; Vilalba, Fábio de Albuquerque; Mironov, Vladimir; Rezende, Rodrigo Alvarenga; Silva, J V da

doi:10.1088/1742-6596/705/1/012010

Cited by 11 publications

(6 citation statements)

References 19 publications

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“…A successful bioprinted tissue and organ usually undergo three steps: pre-printing, printing, and post-printing [ 64 , 65 ]. Figure 4 A describes an at-a-glance flow of printing an organ.…”

Section: Machine-learning Principles Used In 3d Bioprintingmentioning

confidence: 99%

Optimized 3D Bioprinting Technology Based on Machine Learning: A Review of Recent Trends and Advances

Shin

Lee

et al. 2022

Micromachines

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The need for organ transplants has risen, but the number of available organ donations for transplants has stagnated worldwide. Regenerative medicine has been developed to make natural organs or tissue-like structures with biocompatible materials and solve the donor shortage problem. Using biomaterials and embedded cells, a bioprinter enables the fabrication of complex and functional three-dimensional (3D) structures of the organs or tissues for regenerative medicine. Moreover, conventional surgical 3D models are made of rigid plastic or rubbers, preventing surgeons from interacting with real organ or tissue-like models. Thus, finding suitable biomaterials and printing methods will accelerate the printing of sophisticated organ structures and the development of realistic models to refine surgical techniques and tools before the surgery. In addition, printing parameters (e.g., printing speed, dispensing pressure, and nozzle diameter) considered in the bioprinting process should be optimized. Therefore, machine learning (ML) technology can be a powerful tool to optimize the numerous bioprinting parameters. Overall, this review paper is focused on various ideas on the ML applications of 3D printing and bioprinting to optimize parameters and procedures.

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“…A successful bioprinted tissue and organ usually undergo three steps: pre-printing, printing, and post-printing [ 64 , 65 ]. Figure 4 A describes an at-a-glance flow of printing an organ.…”

Section: Machine-learning Principles Used In 3d Bioprintingmentioning

confidence: 99%

Optimized 3D Bioprinting Technology Based on Machine Learning: A Review of Recent Trends and Advances

Shin

Lee

et al. 2022

Micromachines

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“…However, limitations in conventional fabrication techniques such as lack of three-dimensional architecture, cellular positioning at the desired locations, variable cellular density, template requirement, difficulty in complex shape fabrication suggest the usage of advanced fabrication techniques to engineer tissues or organs for transplantation applications. 24,25 Figure 2. (a) Chronological history of 3D printing/bioprinting in potential biomedical applications, (b) imagined future of 3D bioprinting-3D models obtained through CT or MRI images and computationally redesigned according to the personalized requirements.…”

Section: Tissue Engineered Medical Products (Temps)mentioning

confidence: 99%

Section: Tissue Engineered Medical Products (Temps)mentioning

confidence: 99%

Current standards and ethical landscape of engineered tissues—3D bioprinting perspective

et al. 2021

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Tissue engineering is an evolving multi-disciplinary field with cutting-edge technologies and innovative scientific perceptions that promise functional regeneration of damaged tissues/organs. Tissue engineered medical products (TEMPs) are biomaterial-cell products or a cell-drug combination which is injected, implanted or topically applied in the course of a therapeutic or diagnostic procedure. Current tissue engineering strategies aim at 3D printing/bioprinting that uses cells and polymers to construct living tissues/organs in a layer-by-layer fashion with high 3D precision. However, unlike conventional drugs or therapeutics, TEMPs and 3D bioprinted tissues are novel therapeutics and need different regulatory protocols for clinical trials and commercialization processes. Therefore, it is essential to understand the complexity of raw materials, cellular components, and manufacturing procedures to establish standards that can help to translate these products from bench to bedside. These complexities are reflected in the regulations and standards that are globally in practice to prevent any compromise or undue risks to patients. This review comprehensively describes the current legislations, standards for TEMPs with a special emphasis on 3D bioprinted tissues. Based on these overviews, challenges in the clinical translation of TEMPs & 3D bioprinted tissues/organs along with their ethical concerns and future perspectives are discussed.

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“…Post-processing steps are performed on the final product that includes removing the unconsumed fragments, cooling, drilling, cutting, polishing, and sterilization. Also, the end products are being tested to make sure the product has appropriate characteristics or traits that include all its functional properties and strength [64,65].…”

Section: D Bioprintingmentioning

confidence: 99%

3D Printing: Advancement in Biogenerative Engineering to Combat Shortage of Organs and Bioapplicable Materials

Parihar

Pandita

Kumar

et al. 2021

Regen. Eng. Transl. Med.

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Organ or cell transplantation is medically evaluated for end-stage failure saving or extending the lives of thousands of patients who are suffering from organ failure disorders. The unavailability of adequate organs for transplantation to meet the existing demand is a major challenge in the medical field. This led to day-day-increase in the number of patients on transplant waiting lists as well as in the number of patients dying while on the queue. Recently, technological advancements in the field of biogenerative engineering have the potential to regenerate tissues and, in some cases, create new tissues and organs. In this context, major advances and innovations are being made in the fields of tissue engineering and regenerative medicine which have a huge impact on the scientific community is three-dimensional bioprinting (3D bioprinting) of tissues and organs. Besides this, the decellularization of organs and using this as a scaffold for generating new organs through the recellularization process shows promising results. This review discussed about current approaches for tissue and organ engineering including methods of scaffold designing, recent advances in 3D bioprinting, organs regenerated successfully using 3D printing, and extended application of 3D bioprinting technique in the field of medicine. Besides this, information about commercially available 3D printers has also been included in this article. Lay SummaryToday's need for organs for the transplantation process in order to save a patient's life or to enhance the survival rate of diseased one is the prime concern among the scientific community. Recent, advances in the field of biogenerative engineering have the potential to regenerate tissues and create organs compatible with the patient's body. In this context, major advances and innovations are being made in the fields of tissue engineering and regenerative medicine which have a huge impact on the scientific community is three-dimensional bioprinting (3D bioprinting) of tissues and organs. Besides this, the decellularization of organs and using this as a scaffold for generating new organs through the recellularization process shows promising results. This review dealt with the current approaches for tissue and organ engineering including methods of scaffold designing, recent advances in 3D bioprinting, organs regenerated successfully using 3D printing, and extended application of 3D bioprinting technique in the field of medicine. Furthermore, information about commercially available 3D printers has also been included in this article.

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From 3D Bioprinters to a fully integrated Organ Biofabrication Line

Cited by 11 publications

References 19 publications

Optimized 3D Bioprinting Technology Based on Machine Learning: A Review of Recent Trends and Advances

Optimized 3D Bioprinting Technology Based on Machine Learning: A Review of Recent Trends and Advances

Current standards and ethical landscape of engineered tissues—3D bioprinting perspective

3D Printing: Advancement in Biogenerative Engineering to Combat Shortage of Organs and Bioapplicable Materials

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