Frizzled‐9 triggers actin polymerization and activates mechano‐transducer YAP to rescue simulated microgravity‐induced osteoblast dysfunction
Qiusheng Shi,
Jinpeng Gui,
Lianwen Sun
et al.
Abstract:Long‐term spaceflight can result in bone loss and osteoblast dysfunction. Frizzled‐9 (Fzd9) is a Wnt receptor of the frizzled family that is vital for osteoblast differentiation and bone formation. In the present study, we elucidated whether Fzd9 plays a role in osteoblast dysfunction induced by simulated microgravity (SMG). After 1–7 days of SMG, osteogenic markers such as alkaline phosphatase (ALP), osteopontin (OPN), and Runt‐related transcription factor 2 (RUNX2) were decreased, accompanied by a decrease i… Show more
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