Friend or Foe? Locoregional Therapies and Immunotherapies in the Current Hepatocellular Treatment Landscape

Young, Shamar; Hannallah, Jack; Goldberg, Daniel W.; Sanghvi, Tina; Arshad, Junaid; Scott, Aaron J.; Woodhead, Gregory

doi:10.3390/ijms241411434

Cited by 4 publications

(1 citation statement)

References 110 publications

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“…The second of the three articles reviews the development of new treatment options for HCC [ 7 ], the most common primary liver cancer and a leading cause of cancer-related deaths globally. Categorising HCC patients has always been problematic, given the frequent presence of cirrhosis and HCC.…”

mentioning

confidence: 99%

Advances in Molecular Medicine: Unravelling Disease Complexity and Pioneering Precision Healthcare

Bustin,

Jellinger

2023

IJMS

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mentioning

confidence: 99%

Advances in Molecular Medicine: Unravelling Disease Complexity and Pioneering Precision Healthcare

Bustin,

Jellinger

2023

IJMS

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Liver-Directed Therapy Combined with Systemic Therapy: Current Status and Future Directions

Young,

Hannallah,

Goldberg

et al. 2023

Semin intervent Radiol

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In the past several decades, major advances in both systemic and locoregional therapies have been made for many cancer patients. This has led to modern cancer treatment algorithms frequently calling for active interventions by multiple subspecialists at the same time. One of the areas where this can be clearly seen is the concomitant use of locoregional and systemic therapies in patients with primary or secondary cancers of the liver. These combined algorithms have gained favor over the last decade and are largely focused on the allure of the combined ability to control systemic disease while at the same time addressing refractory/resistant clonal populations. While the general concept has gained favor and is likely to only increase in popularity with the continued establishment of viable immunotherapy treatments, for many patients questions remain. Lingering concerns over the increase in toxicity when combining treatment methods, patient selection, and sequencing remain for multiple cancer patient populations. While further work remains, some of these questions have been addressed in the literature. This article reviews the available data on three commonly treated primary and secondary cancers of the liver, namely, hepatocellular carcinoma, cholangiocarcinoma, and metastatic colorectal cancer. Furthermore, strengths and weaknesses are reviewed and future directions are discussed.

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Thermal Ablation in the Liver: Heat versus Cold—What Is the Role of Cryoablation?

D'Souza,

Ragulojan,

Guo

et al. 2023

Semin intervent Radiol

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Cryoablation is commonly used in the kidney, lung, breast, and soft tissue, but is an uncommon choice in the liver where radiofrequency ablation (RFA) and microwave ablation (MWA) predominate. This is in part for historical reasons due to serious complications that occurred with open hepatic cryoablation using early technology. More current technology combined with image-guided percutaneous approaches has ameliorated these issues and allowed cryoablation to become a safe and effective thermal ablation modality for treating liver tumors. Cryoablation has several advantages over RFA and MWA including the ability to visualize the ice ball, minimal procedural pain, and strong immunomodulatory effects. This article will review the current literature on cryoablation of primary and secondary liver tumors, with a focus on efficacy, safety, and immunogenic potential. Clinical scenarios when it may be more beneficial to use cryoablation over heat-based ablation in the liver, as well as directions for future research, will also be discussed.

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Friend or Foe? Locoregional Therapies and Immunotherapies in the Current Hepatocellular Treatment Landscape

Cited by 4 publications

References 110 publications

Advances in Molecular Medicine: Unravelling Disease Complexity and Pioneering Precision Healthcare

Advances in Molecular Medicine: Unravelling Disease Complexity and Pioneering Precision Healthcare

Liver-Directed Therapy Combined with Systemic Therapy: Current Status and Future Directions

Thermal Ablation in the Liver: Heat versus Cold—What Is the Role of Cryoablation?

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