Friend or Foe

Annis, Sofia; Safdar, Adeel; Biala, Eduardo; Saleem, Ayesha; Li, Housaiyin; Gandhi, Priya; Fleischmann, Zoë; Castaneda‐Sceppa, Carmen; Tilly, Jonathan L.; Woods, Dori C.; Khrapko, Konstantin

doi:10.1002/9781119329725.ch31

Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants 2018

DOI: 10.1002/9781119329725.ch31

|View full text |Cite

Friend or Foe

Sofia Annis

Adeel Safdar

Eduardo Biala

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

Publication Types

Select...

Preprint1

Relationship

Self Cite1

Independent0

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…stem mtDNA descends only from stem mtDNA, which is essential for keeping a pure, mutation-free lineage. We have previously reported that mutational patterns in mtDNA mutator PolG mouse imply the possibility of lineal separation of powers between cellular mitochondria (Annis et al 2018), (Safdar et al 2016), though other interpretations could not be ruled out.…”

mentioning

confidence: 95%

The ‘Stem’ and the ‘Workers’ of the mtDNA population of the cell. Evidence from mutational analysis

Cote-L'Heureux

Franco

Maithania

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Every cell in our body contains a vibrant population of mitochondria, or, more precisely, of mitochondrial DNA molecules (mtDNAs). Just like members of any population mtDNAs multiply (by replication) and die (i.e., are removed, either by degradation or by distribution into the sister cell in mitosis). An intriguing question is whether all mitochondria in this population are equal, especially whether some are responsible primarily for reproduction and some - for empowering the various jobs of the mitochondrion, oxidative phosphorylation in the first place. Importantly, because mtDNA is highly damaged such a separation of responsibilities could help greatly reduce the conversion of DNA damage into real inheritable mutations. An unexpected twist in the resolution of this problem has been brought about by a recent high-precision analysis of mtDNA mutations (Sanchez-Contreras et al. 2023). They discovered that certain transversion mutations, unlike more common transitions, are not accumulating with age in mice. We argue that this observation requires the existence of a permanent replicating subpopulation/lineage of mtDNA molecules, which are protected from DNA damage, a.k.a. the stem mtDNA. This also implies the existence of its antipode i.e., the worker mtDNA, which empowers OSPHOS, sustains damage and rarely replicates. The analysis of long HiFi reads of mtDNA performed by PacBio closed circular sequencing confirms this assertion.

show abstract

mentioning

confidence: 95%

The ‘Stem’ and the ‘Workers’ of the mtDNA population of the cell. Evidence from mutational analysis

Cote-L'Heureux

Franco

Maithania

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Friend or Foe

Cited by 1 publication

References 95 publications

The ‘Stem’ and the ‘Workers’ of the mtDNA population of the cell. Evidence from mutational analysis

The ‘Stem’ and the ‘Workers’ of the mtDNA population of the cell. Evidence from mutational analysis

Contact Info

Product

Resources

About