Fried’s Frailty Phenotype Predicts Overall Survival for Older Hematopoietic Cell Transplantation Recipients

Sung, Anthony D.; Koll, Thuy T.; Gier, Shannon; Lew, M.; Free, Marcia M; Bohannon, Lauren; Racioppi, Alessandro; Babushok, Daria V.; Frey, Noelle V.; Gill, Saar; Hexner, Elizabeth O.; Martin, Mary Ellen; Perl, Alexander E.; Pratz, Keith W.; Luger, Selina M.; Stadtmauer, Edward A.; Porter, David L.; Loren, Alison W.; Bhatt, Vijaya Raj; Gimotty, Phyllis A.; McCurdy, Shannon R.

doi:10.1016/s2666-6367(21)00082-8

Cited by 4 publications

(4 citation statements)

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“…In a recent collaborative study at three HCT centers of patients 60 years and older who underwent HCT, we demonstrated that patients over 70 had higher NRM than patients in their 60s, albeit with no difference in relapse. In addition we found that age, frailty, Karnosfky performance status, and disease risk index could be utilized together to predict survival time for older adults after HCT 64 . Pre‐frail and frail older adults had a higher risk of relapse and relapse‐related mortality then fit older adults.…”

Section: Geriatric Assessmentsmentioning

confidence: 82%

“…In addition we found that age, frailty, Karnosfky performance status, and disease risk index could be utilized together to predict survival time for older adults after HCT. 64 Pre-frail and frail older adults had a higher risk of relapse and relapse-related mortality then fit older adults. Our findings mirrored that of Muffly et al who found that slow gait speed pre-HCT was associated with inferior OS due to a higher risk of relapse.…”

Section: Geriatric Assessmentsmentioning

confidence: 99%

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Age barriers in allogeneic hematopoietic cell transplantation: Raising the silver curtain

Munshi,

McCurdy

2024

American J Hematol

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Allogeneic hematopoietic cell transplantation (HCT) is no longer exclusively for the young. With an aging population, development of non‐intensive remission‐inducing strategies for hematologic malignancies, and novel graft‐versus‐host disease‐prevention platforms, an older population of patients is pursuing HCT. The evolving population of HCT recipients requires an overhaul in the way we risk‐stratify and optimize patients prior to HCT. Here, we review the history and current state of HCT for older adults and propose an assessment and intervention flow to bridge the gaps in today's clinical guidelines.

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Section: Geriatric Assessmentsmentioning

confidence: 82%

Section: Geriatric Assessmentsmentioning

confidence: 99%

Age barriers in allogeneic hematopoietic cell transplantation: Raising the silver curtain

Munshi,

McCurdy

2024

American J Hematol

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“…With the increasing number of older adults receiving allogeneic HCT, there is an increased awareness of the importance of frailty and functionality prior to allogeneic HCT [ 1 ]. Ten to 33% of older adults are found to be frail prior to undergoing HCT [ 2 – 4 ]. In studies inclusive of all adults or younger adults, frailty is seen in 36% and 26%, respectively, prior to HCT, demonstrating that frailty is not limited to older adults [ 4 , 5 ].…”

mentioning

confidence: 99%

“…In studies inclusive of all adults or younger adults, frailty is seen in 36% and 26%, respectively, prior to HCT, demonstrating that frailty is not limited to older adults [ 4 , 5 ]. Frail adults have been shown to have decreased overall survival (OS), increased non-relapse mortality (NRM), and increased toxicities posttransplant [ 2 – 4 , 6 ]. A major component of frailty includes an evaluation of impairments in instrumental activities of daily living (IADLs), activities required for individuals to live independently in the community.…”

mentioning

confidence: 99%