Friction properties of a new silk fibroin scaffold for meniscal replacement

Warnecke, Daniela; Schild, Natalie; Klose, Svenja; Joos, Helga; Brenner, Rolf E.; Kessler, Oliver; Skaer, Nick; Walker, Robert; Freutel, Maren; Ignatius, Anita; Dürselen, Lutz

doi:10.1016/j.triboint.2017.01.038

Cited by 23 publications

(28 citation statements)

References 37 publications

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“…We recently reported friction coefficients of around 0.056 of a silk fibroin scaffold for partial meniscal replacement, which is in the range of the requirements for meniscal replacements postulated by Rongen et al . 17,18 .…”

Section: Introductionmentioning

confidence: 99%

Articular cartilage and meniscus reveal higher friction in swing phase than in stance phase under dynamic gait conditions

Warnecke¹,

Meßemer²,

Roy³

et al. 2019

Sci Rep

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Most previous studies investigated the remarkably low and complex friction properties of meniscus and cartilage under constant loading and motion conditions. However, both load and relative velocity within the knee joint vary considerably during physiological activities. Hence, the question arises how friction of both tissues is affected by physiological testing conditions occurring during gait. As friction properties are of major importance for meniscal replacement devices, the influence of these simulated physiological testing conditions was additionally tested for a potential meniscal implant biomaterial. Using a dynamic friction testing device, three different friction tests were conducted to investigate the influence of either just varying the motion conditions or the normal load and also to replicate the physiological gait conditions. It could be shown for the first time that the friction coefficient during swing phase was statistically higher than during stance phase when varying both loading and motion conditions according to the physiological gait pattern. Further, the friction properties of the exemplary biomaterial were also higher, when tested under dynamic gait parameters compared to static conditions, which may suggest that static conditions can underestimate the friction coefficient rather than reflecting the in vivo performance.

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Section: Introductionmentioning

confidence: 99%

Articular cartilage and meniscus reveal higher friction in swing phase than in stance phase under dynamic gait conditions

Warnecke¹,

Meßemer²,

Roy³

et al. 2019

Sci Rep

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“…A silk fibroin scaffold (FibroFix™; Orthox Ltd., Abingdon, UK) was previously developed and investigated in several in vitro and in vivo studies . The in vivo performance of the first generation of silk fibroin scaffolds was evaluated in a partial meniscal defect in the ovine model .…”

Section: Introductionmentioning

confidence: 99%

Meniscal Replacement With a Silk Fibroin Scaffold Reduces Contact Stresses in the Human Knee

Stein

Höse

Warnecke

et al. 2019

Journal Orthopaedic Research

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The aim of the current study was to verify if a previously developed silk fibroin scaffold for meniscal replacement is able to restore the physiological distribution of contact pressure (CP) over the articulating surfaces in the human knee joint, thereby reducing peak loads occurring after partial meniscectomy. The pressure distribution on the medial tibial articular surface of seven human cadaveric knee joints was analysed under continuous flexion-extension movements and under physiological loads up to 2,500 N at different flexion angles. Contact area (CA), maximum tibiofemoral CP, maximum pressure under the meniscus and the pressure distribution were analysed for the intact meniscus, after partial meniscectomy as well as after partial medial meniscal replacement using the silk fibroin scaffold. Implantation of the silk fibroin scaffold considerably improved tibiofemoral contact mechanics after partial medial meniscectomy. While the reduced CA after meniscectomy was not fully restored by the silk fibroin scaffold, clinically relevant peak pressures on the articular cartilage surface occurring after partial meniscectomy were significantly reduced. Nevertheless, at high flexion angles static testing demonstrated that normal pressure distribution comparable to the intact meniscus could not be fully achieved. The current study demonstrates that the silk fibroin implant possesses attributes that significantly improve tibiofemoral CPs within the knee joint following partial meniscectomy. However, the failure to fully recapitulate the CAs and pressures observed in the intact meniscus, particularly at high flexion angles, indicates that the implant's biomechanical properties may require further improvement to completely restore tibiofemoral contact mechanics.

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“…Therefore, the material was subjected to an optimisation process and a silk fibre mesh was integrated into the porous matrix to improve anchoring of the fixation sutures. Recently, we investigated the frictional properties of this second generation of silk fibroin scaffolds ( Warnecke et al, 2017 ). The scaffold, in comparison to the physiologically articulating surfaces of the meniscus and articular cartilage, displayed slightly higher friction coefficients than the native meniscus ( Warnecke et al, 2017 ), but still remaining within the range of the mentioned requirements ( Stone, 1996 , Stone et al, 1997 , Rongen et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Biomechanical, structural and biological characterisation of a new silk fibroin scaffold for meniscal repair

Warnecke

Stein

Haffner‐Luntzer

et al. 2018

Journal of the Mechanical Behavior of Biomedical Materials

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Meniscal injury is typically treated surgically via partial meniscectomy, which has been shown to cause cartilage degeneration in the long-term. Consequently, research has focused on meniscal prevention and replacement. However, none of the materials or implants developed for meniscal replacement have yet achieved widespread acceptance or demonstrated conclusive chondroprotective efficacy.A redesigned silk fibroin scaffold, which already displayed promising results regarding biocompatibility and cartilage protection in a previous study, was characterised in terms of its biomechanical, structural and biological functionality to serve as a potential material for permanent partial meniscal replacement. Therefore, different quasi-static but also dynamic compression tests were performed. However, the determined compressive stiffness (0.56 ± 0.31 MPa and 0.30 ± 0.12 MPa in relaxation and creep configuration, respectively) was higher in comparison to the native meniscal tissue, which could potentially disturb permanent integration into the host tissue. Nevertheless, µ-CT analysis met the postulated requirements for partial meniscal replacement materials in terms of the microstructural parameters, like mean pore size (215.6 ± 10.9 µm) and total porosity (80.1 ± 4.3%). Additionally, the biocompatibility was reconfirmed during cell culture experiments. The current study provides comprehensive mechanical and biological data for the characterisation of this potential replacement material. Although some further optimisation of the silk fibroin scaffold may be advantageous, the silk fibroin scaffold showed sufficient biomechanical competence to support loads already in the early postoperative phase.

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Friction properties of a new silk fibroin scaffold for meniscal replacement

Cited by 23 publications

References 37 publications

Articular cartilage and meniscus reveal higher friction in swing phase than in stance phase under dynamic gait conditions

Articular cartilage and meniscus reveal higher friction in swing phase than in stance phase under dynamic gait conditions

Meniscal Replacement With a Silk Fibroin Scaffold Reduces Contact Stresses in the Human Knee

Biomechanical, structural and biological characterisation of a new silk fibroin scaffold for meniscal repair

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