FRI0581 Utility of the Glasgow Prognostic Score in Systemic Lupus Erythematosus, In a Single Center Cohort of 130 Patients

Delcea, Caterina; Dima, Alina; Jurcuţ, Ciprian; Caraiola, Simona; Badea, Camelia; Nitescu, D.; Bălănescu, Eugenia; Nicolau, Adriana; Pompilian, V.; Ionescu, R; Băicuș, Cristian; Dan, Gheorghe Andrei

doi:10.1136/annrheumdis-2015-eular.6081

Cited by 7 publications

(6 citation statements)

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“…In SLE patients, GPS was correlated with disease activity. 49 Although slightly to moderately increased levels seem to be frequently observed in active lupus, 47 CRP is not one of the recommended tools in SLE disease activity follow-up, [32][33][34] as its kinetics does not seem to be similar in all SLE patients. Mok et al 50 found detectable hsCRP in almost 80% of SLE patients with active clinical manifestations, but stronger associations were observed only in cases presenting with serositis, musculoskeletal, and/or hematological involvements.…”

Section: C-reactive Protein and Erythrocyte Sedimentation Rate Discordance In Patients With Systemic Lupus Erythematosusmentioning

confidence: 99%

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Is there still a place for erythrocyte sedimentation rate and C-reactive protein in systemic lupus erythematosus?

Dima

Opriş

Jurcuţ³

et al. 2016

Lupus

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The inflammatory response during systemic lupus erythematosus (SLE) flares is known to be atypical, characterized by a disproportionately lower C-reactive protein (CRP) elevation when compared with erythrocyte sedimentation rate (ESR). Thus, in these patients, the analysis of inflammatory markers might be challenging in daily clinical practice. Clinicians need frequently to distinguish lupus reactivations and infectious conditions, and the significance of ESR and CRP seems to be different. Even though a non-specific marker of inflammation, ESR utility in SLE should not be neglected and it appears to be a useful biomarker for SLE activity assessment. Describing a specific cut-off for ESR in SLE is important for patients' follow-up, and levels up to 25-30 mm/h have been proposed as an upper limit of the normal range. Regarding CRP, even though higher baseline levels are described in SLE when compared with controls, including in remission periods, its response during flares seems to be incomplete and not always correlated with disease activity; while CRP values greater than 10 mg/l could be indicative for severe flares, when there is no serositis or arthritis, higher CRP levels above 50-60 mg/l may be associated with infection.

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Section: C-reactive Protein and Erythrocyte Sedimentation Rate Discordance In Patients With Systemic Lupus Erythematosusmentioning

confidence: 99%

“…In SLE patients, GPS was correlated with disease activity. 49…”

Section: C-reactive Protein and Erythrocyte Sedimentation Rate Discordance In Patients With Systemic Lupus Erythematosusmentioning

confidence: 99%

Is there still a place for erythrocyte sedimentation rate and C-reactive protein in systemic lupus erythematosus?

Dima

Opriş

Jurcuţ³

et al. 2016

Lupus

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“…Modified Glasgow Prognostic Score (mGPS), based on the level of serum CRP and albumin (Table 1 ), has been effectively used for predicting the outcome of gastrointestinal cancer 16 . Moreover, mGPS has been used in other diseases like systemic lupus erythematosus (SLE) and acute decompensated heart failure (ADHF) 17 , 18 . It provides more prognostic information in terms of the severity and prognosis for malignant tumor compared to the neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR), which have been widely used in IBD 19 – 21 .…”

Section: Introductionmentioning

confidence: 99%

Validation and optimization of the Systemic Inflammation-Based modified Glasgow Prognostic Score in predicting postoperative outcome of inflammatory bowel disease: preliminary data

Zhao

Ding

Xie

et al. 2018

Sci Rep

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Systemic Inflammation-Based modified Glasgow Prognostic Score (mGPS) was developed as an objective tool to grade state of inflammation. However, the association between mGPS and postoperative complications for inflammatory bowel disease (IBD) patients was still unknown. In our study, 270 IBD patients [Crohn’s disease (CD), n = 186; Ulcerative colitis (UC), n = 84] from January 2013 and January 2016 who underwent elective bowel resection were retrospectively analyzed, and, the levels of preoperative C-reactive protein (CRP) and albumin were included as parameters of mGPS. The incidence of overall postoperative complications was 44.81% (121/270), including 46.77% (87/186) of CD and 40.48% (34/84) of UC. According to multivariate analysis, mGPS (CD: OR = 3.47, p = 0.003; UC: OR = 3.28, p = 0.019) was independently associated with an increased risk of postoperative complications. Patients with a higher mGPS also suffered longer postoperative stay and increased SSIs (both p < 0.05). Combining mGPS with neutrophil ratio improved its prognostic value with a better area under the curve (AUC), using receiver operating characteristic (ROC) method. Then we confirmed that mGPS was associated with postoperative complications in IBD patients undergoing elective bowel resection and the addition of neutrophil ratio enhanced its prognostic value.

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“…The sample size was calculated according to the cut-off values of inflammatory biomarkers ROC curves published in previous studies [ 3 , 4 , 5 , 6 , 7 , 8 ]. 50% of reduction/normalisation of pathological biomarkers (50 to 100%) was assumed.…”

Section: Methodsmentioning

confidence: 99%

“…Described by Glotzer et al in 1981 [ 2 ], it is characterized by endoscopic findings such as mucosal friability, oedema, erythema, appearance of polyps, ulcers, stenosis, and microscopic findings such as lymphoid follicular hyperplasia, infiltration of the lamina propria by lymphocytes, eosinophils, the appearance of plasma cells, architectural disruption, and the appearance of crypt abscesses [ 1 ]. Chronic inflammation produces an increase of serum biomarkers, like other systemic inflammatory diseases such as gastrointestinal tumour, systemic lupus erythematosus, inflammatory bowel disease and cardiovascular disease [ 3 , 4 , 5 , 6 ]. The Glasgow Pronostic Score (GPS) and its modified scale (mGPS) were used to quantify the inflammatory state, based on serum levels of C-reactive protein (CRP) and albumin [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Serological Biomarkers and Diversion Colitis: Changes after Stimulation with Probiotics

et al. 2021

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Diversion colitis is a non-specific inflammation of a defunctionalised segment of the colon after a temporary stoma has been performed. This inflammation is associated with an alteration of certain inflammatory serum markers. The aims of this study were, firstly, to evaluate the modification of inflammatory biomarkers after stimulation with probiotics prior to closure of the protective ileostomy. Secondly, to identify if a relationship could be established between the severity of diversion colitis and the alteration of inflammatory biomarkers in the blood. A prospective, randomized, double-blind, controlled study was conducted. Patients who underwent surgery for colorectal carcinoma with protective ileostomy between January 2017 and December 2018 were included, pending reconstructive surgery and with diversion colitis as diagnosis. The sample was randomly divided into a group stimulated with probiotics (SG) (n = 34) and a control group (CG) (n = 35). Histological and endoscopic changes were evaluated after stimulation, after restorative surgery and during the short-term follow-up after surgery, including the correlation with pro-inflammatory biomarkers in blood. As main findings, a significant decrease in C-reactive protein (CRP), Neutrophil/lymphocyte ratio (NLR ratio), and monocyte/lymphocyte ratio (LMR ratio) was observed in the SG versus the CG with a p < 0.001. A significant increase in transferrin values and in the platelet/lymphocyte ratio (PLR) was observed in the SG versus CG after stimulation with probiotics with a p < 0.001. A normalisation of CRP and transferrin levels was observed in the third month of follow-up after closure ileostomy, and NLR, LMR and PLR ratios were equal in both groups. Decreased modified Glasgow prognostic score was found in SG compared to CG after probiotic stimulation (p < 0.001). The endoscopic and histological severity of diversion colitis is associated with a greater alteration of blood inflammatory biomarkers. The stimulation with probiotics prior to reconstructive surgery promotes an early normalization of these parameters.

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FRI0581 Utility of the Glasgow Prognostic Score in Systemic Lupus Erythematosus, In a Single Center Cohort of 130 Patients

Cited by 7 publications

References 0 publications

Is there still a place for erythrocyte sedimentation rate and C-reactive protein in systemic lupus erythematosus?

Is there still a place for erythrocyte sedimentation rate and C-reactive protein in systemic lupus erythematosus?

Validation and optimization of the Systemic Inflammation-Based modified Glasgow Prognostic Score in predicting postoperative outcome of inflammatory bowel disease: preliminary data

Serological Biomarkers and Diversion Colitis: Changes after Stimulation with Probiotics

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