FRI0581 Hepatitis b increase mortality in pateints with osteoporotic vertebral fractures

Abstract

BackgroundHepatitis B virus (HBV) is a major cause of chronic liver diseases worldwide, particularly cirrhosis and hepatocellular carcinoma, and the most important liver disease in Taiwan. However, little is known the impact of hepatitis b on osteoporotic patients.ObjectivesThis study aimed to determine if hepatitis b can increase the risk of mortality in patients with osteoporotic vertebral fracture.MethodsThis retrospective study reviewed of cases of osteoporosis patients with acute vertebral fractures between 2001 and 2008. All associated co-morbidities were recorded. Kaplan-Meier and cox regression analysis were performed.ResultsThere were 432 patients with acute vertebral fractures. The mean age of 72.85±9.28. 31 (7.2%) patients had chronic hepatitis b. Using the Kaplan-Meier curve, hepatitis b had a significant effect on mortality (p<0.001, by log rank text). After adjusting for potential confounders, patients with hepatitis b still had a high mortality rate (p=0.019; HR: 2.436∼5.136) 2.137, 95% CI: 1.156∼5.136). The mortality rate also increased among smokers (p=0.026; HR: 3.6043.891; 95% CI: 1.056∼12.301).Table 1.Multivariable Cox regression analysis of the hazard ratios for adjacent fractureVariablesRegression coefficientP valueHR (95CI) Gender-0.1270.7640.88 (0.383–0.022)Age0.0040.7851.004 (0.976–1.032)Smoking1.2820.0413.604 (1.056–12.301)Alcohol consumption-0.7010.3960.496 (0.098–2.508)Body mass index (kg/m2)0.0240.4461.024 (0.964–1.088)Hepatitis B0.8910.0192.436 (1.156–5.136)Diabetes-0.1850.5380.831 (0.461–1.498)Hypertension-0.2710.310.762 (0.451–1.288)Stroke-0.6960.2480.499 (0.153–1.625)Kidney disease0.8090.1452.246 (0.758–6.656)Cardiovascular disease0.0370.9461.038 (0.351–3.069)Pulmonary disease-0.9710.3490.379 (0.050–2.883)Abbreviations: HR, hazard ratio; SE, standard error.ConclusionsIn this study, hepatitis b increase mortality in osteoporotic vertebral fracture patients. So we should pay attention to this group in osteoporotic management.References Chong-Shan Wang et al. Am. J. Trop. Med. Hyg., 66(4), 2002, pp. 389–393. AcknowledgementsWe thank Kaohsiung Chang Gang Memorial Hospital for data support.Disclosure of InterestNone declared