FRI0553 The role of age-related sarcopenia in osteoarthritis of lower extremity

Abstract

BackgroundSarcopenia, defined as the age-related loss of muscle mass and low muscle function.1 The prevalence of sarcopenia worldwide by meta-analysis of 35 articles was 10% (95% CI: 8%–12%) in men and 10% (95% CI: 8%–13%) in women, respectively.2 A review of the literature on osteoarthritis (OA) and sarcopenia has shown that the age factor that contributes to the development of OA includes a decrease in muscle strength. In people with OD of the lower extremity, the frequency of falls was increased by a factor of 2–5.3 OA contributed to the development of sarcopenia in elderly women.4 ObjectivesPerform body composition and muscle analysis in patients with osteoarthritis and identify risk factors for sarcopenia that affect patients with osteoarthritis.MethodsProspective study of 159 women, mean age 74±13.3. The walking speed, handgrip strength were evaluated to apply the European Working Group on Sarcopenia. Assessment of appendicular skeletal muscle mass (ALM/h2) and total body fat were assessed using DXA, on Hologic Explorer machines. Covariates were determined by questionnaires and interviews.Results31.45% of people with OA older than 65 years had sarcopenia. Patients with OA had a decrease in muscle strength and function, regardless of sarcopenia. Statistically significantly more frequent in patients with OA were lower indexes of lean mass index (ALM/h2) and body mass index (BMI) (p<0.01). The incidence of sarcopenia increased with age (p<0.01). 61.5% of patients with sarcopenia significantly more often had high values of c-reactive protein – CRP (x2=31.18, p<0.0001). Patients with sarcopenia were statistically significantly more likely to have vitamin D deficiency than patients without sarcopenia (x2=8.11, p<0.01). Cases of falls were observed in 90% of patients with sarcopenia (x2=79.29, p<0.001). Low physical activity 86% of patients with sarcopenia are statistically significantly higher than in patients without sarcopenia (95% CI: 73.3–94.2, p<0.01).ConclusionsWith age, patients with sarcopenia and OA had a significant decrease in muscle mass and physical activity, an increase in the incidence of falls. Patients with sarcopenia had high CRP levels and vitamin D deficiency than patients without sarcopenia.References[1] Milte R, Crotty M. Musculoskeletal health, frailty and functional decline. Best Pract Res Clin Rheumatol. 2014;28(3):395–410.[2] Shafiee G, Keshtkar A, Soltani A, et al. Prevalence of sarcopenia in the world: a systematic review and meta- analysis of general population studies. Journal of Diabetes & Metabolic Disorders2017;16:21.[3] Hoops ML, Rosenblatt NJ, Hurt CP, Crenshaw J, Grabiner MD. Does lower extremity osteoarthritis exacerbate risk factors for falls in older adults?Womens Health (Lond Engl)2012;8(6):685–96.[4] Kemmler W, Teschler M, Goisser S, Et al. Prevalence of sarcopenia in germany and the corresponding effect of osteoarthritis in females 70 years and older living in the community: results of the FOrMosA study. Clinical Interventions in Aging2015;10:1565–1573.Disclosure of Intere...

Вплив Національних Чинників На Формування Субрегіональної Політики Держав Центральної Європи

“…У період із 1994 по 1997 рр. Вишеградська група не збиралася жодного разу, вважаючи, що індивідуальні зусилля щодо вступу до євроатлантичних інтеграційних формувань будуть більш ефективними [12,72]. Цей етап характеризується українським науковцем В. Лебедюком як період стагнації в субрегіональному співробітництві у Вишеградській групі [11, с.…”