FRI0453 Clinical and therapeutic characterization of a colombian cohort with spondyloarthropathies

Abstract

BackgroundSpondyloarthropathies (SpAs) are a group of auto-inflammatory diseases, with overlapping symptoms, that include ankylosing spondylitis (AS), psoriatic arthritis (PsA), undifferentiated spondyloarthritis (Und SpA), enteropathic arthritis, and reactive arthritis (1).ObjectivesTo characterize the disease in a large Colombian cohort with SpAs, assessing differences in its classification, clinical manifestations, laboratory results, radiographic changes, and treatment, according to the type of SpA.MethodsA cross-sectional study was conducted in 621 patients with SpAs, in whom sociodemographic, clinical and therapeutic characteristics were analyzed based on the type of diagnosis. Statistical association was examined by means of Chi-square tests, Fisher's exact test, Mann-Whitney test, and logistic regression analyses. In all cases, a p value <0.05 was considered significant.ResultsOut of the 621 patients included, AS was observed in 54,7%, PsA in 35,7%, and Und SpA in 9,5%. AS was positively associated to male gender (OR 2.05 95%IC 1.5–2.8), younger age at onset, axial involvement (OR 23.2 95%IC 15.2–35.5), uveitis (OR 3.8 95%IC 2.25–6.57), radiographic sacroilitis (OR 6.95 95%IC 3.02–16.02), and HLA-B27 positivity (OR 2.3 95%IC 1.5- 3.5). PsA was associated to female gender, older age at onset, arthritis, and peripheral involvement. According to the therapeutic approach, more use of conventional DMARD therapy was found in PsA and Und SpA, while more use of biology therapy in AS.Table 1.General characteristics of patients with SpAsAllASPsAUnd SpAp-value N=621N=340N=222N=59 N%N%N%N% Mean (SD) Age, year49.3 (12.4)45.2 (12.5)56.7 (11.8)45.9 (12.9) <0.0001 Age at diagnostic, year40.1 (12.9)33.5 (12.6)46.8 (13.5)39.9 (12.5) <0.0001 Male32852.820861.19643.22440.6 <0.0001 Age at onset, <45 years46975.529185.514063.13864.4 <0.0001 Low back pain34255.126678.24721.22949.2 <0.0001 Arthritis41166.215244.7213964678 <0.0001 Enthesitis21734.913640.3716.74474.60.38Dactylitis11618.74914.44520.32237.3 0.0002 Psoriasis22536.230.8822199.611.7 <0.0001 Uveitis9214.87522.173.21016.9 <0.0001 Family history10817.45516.24721.2610.20.09Sacroilitis (Rx)70/17140.962/11653.57/3718.91/185.6 <0.0001 Sacroilitis (MRI)203/27972.8182/21285.921/3953.90/280.0 <0.0001 HLA-B27284/43864.8229/32171.317/6127.938/5667.9 <0.0001 Axial39763.932896.53716.83254.2 <0.0001 Peripheral48878.621362.621898.25796.6 <0.0001 Both26442.520159.13314.93050.9 <0.0001 SD, standard deviation; Rx, radiography; MRI, Magnetic resonance.ConclusionsTo our knowledge, this is the larger existing cohort with SpAs in Colombia. Understanding the natural history of disease is important to do an early diagnosis and treatment that could prevent irreversible disability.References Ehrenfeld M. Spondyloarthropathies. Best Pract Res Clin Rheumatol. 2012;26(1):135–45. AcknowledgementsNone.Disclosure of InterestNone declared