FRI0280 Cd4+cd25highfoxp3+ t regulatory cells as a biomarker of disease activity in systemic lupus erythematosus: a prospective study

Abstract

In multivariate regression analysis, duration of anemia was independently associated with the presence of PAH in SLE patients (P=0.006). When patients were divided into three groups according to tertiles of Hb well as PASP, serum IL-6 significantly increased across the tertiles of PASP (P for trend=0.038), but decreased across the tertiles of Hb (P for trend=0.001). Conclusions: Our study suggests that prolonged exposure to anemic hypoxia, which is associated with increased serum IL-6, might be a component of pathogenesis of PAH in SLE patients. Acknowledgedments: Nothing specified.

The regulation of the Treg/Th17 balance by mesenchymal stem cells in human systemic lupus erythematosus

“…12 Moreover, the frequency of Th17 cells, as well as the related cytokines in the serum, including IL-6, IL-1b, and IL-23, and signal transducer and activator of transcription 3 activity, was higher in SLE patients and down-regulated by disease treatment. 13 Breaking the Th17/Treg balance in peri- pheral blood may play an important role in the development of SLE and could be responsible for an increased pro-inflammatory response, especially in the active form of the disease.…”

The influence of therapy on CD4+CD25highFOXP3+ regulatory T cells in systemic lupus erythematosus patients: a prospective study

“…In this context, several studies have demonstrated quantitative and/or qualitative defects in Tregs in patients with SLE (3)(4)(5)(6)(7); however, other investigators have failed to confirm these results (8,9). Tregs have also been shown to correlate inversely with disease activity, with significant decrements during relapse and increments after disease remission (2,7).…”

Interleukin-35 as a New Biomarker of Renal Involvement in Lupus Nephritis Patients

“…Furthermore, it has been suggested by several studies that regulatory T cells (Treg), as well as its associated cytokines such as interleukin , play a pivotal role in the progression of SLE (Valencia et al 2007;Bonelli et al 2008;Tselios et al 2014;Cai et al 2015a, b).…”