Abstract:BackgroundInflammasomes are cytoplasmic multiprotein complexes that recognise various exogenous and endogenous danger signals in myeloid cells, particularly macrophages. Inflammasome activation eventually induces inflammatory responses in macrophages by activating gasdermin-d-mediated pyroptosis and the secretion of pro-inflammatory cytokines including interleukin (IL)−1β and IL-18 in a caspase-1-dependent manner. The production of IL-1 has been found to be highly induced in AS1 and caspase-1 level was signifi… Show more
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