Abstract:BackgroundOsteoporosis and related fragility fractures are one of the most common complications seen in patients with rheumatoid arthritis (RA). Increased osteoclast activity contributes to local and systemic abnormalities of bone remodelling, including bone erosions and focal and systemic osteoporosis. Receptor Activator of Nuclear Factor Kappa Beta Ligand (RANKL) is essential for osteoclast formation, function, and survival, and it is a key mediator of increased osteoclast activity in RA. As fracture prevent… Show more
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