Fri0093 factors Associated With Refractory Rheumatoid Arthritis (Rra) According to Three Available Definitions: Two Cross-Sectional Analyses in a Large Italian Monocentric Cohort
Abstract:Background:Three definitions of refractory rheumatoid arthritis (RRA) have been proposed: Buch’s (B-RRA), i.e. failure of ≥1 anti-cytokine and ≥1 cell-targeted bDMARD [1]; Kearsley-Fleet’s (KF-RRA), i.e. exposure to ≥3 bDMARDs classes [2]; De Hair’s (DH-RRA), i.e. signs and/or symptoms of RA activity and failure of ≥1 csDMARD and ≥2 bDMARDs [3].Objectives:To evaluate the rate of RRA according to the three definitions in a monocentric cohort with two cross-sectional analyses in 2012 and 2019. We investigated al… Show more
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